Genetic approaches to the molecular understanding of type 2 diabetes (Q34731596)

4 August 2017

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title

Genetic approaches to the molecular understanding of type 2 diabetes (English)

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4 August 2017

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2

Philippe Froguel

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Mark McCarthy

series ordinal

1

object named as

Mark I McCarthy

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PubMed ID

12110525

4 August 2017

language of work or name

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1 August 2002

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American Journal of Physiology - Endocrinology and Metabolism

4 August 2017

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4 August 2017

283

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4 August 2017

2

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4 August 2017

E217-25

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A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

4 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Human type 1 diabetes and the insulin gene: principles of mapping polygenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A transcription factor regulatory circuit in differentiated pancreatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Linkage of genetic markers on human chromosomes 20 and 12 to NIDDM in Caucasian sib pairs with a history of diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A comprehensive linkage analysis for myocardial infarction and its related risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Mouse mutagenesis-systematic studies of mammalian gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A genomewide search for type 2 diabetes-susceptibility genes in indigenous Australians

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Association study designs for complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Parameters for reliable results in genetic association studies in common disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A genome-wide search for human type 1 diabetes susceptibility genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genomewide search for type 2 diabetes susceptibility genes in four American populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

High-throughput genotyping assay approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genetic dissection of complex traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

21 January 2018

1 reference

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Susceptibility gene discovery for common metabolic and endocrine traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Molecular diagnostics in monogenic and multifactorial forms of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

New drug targets for type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Are rare variants responsible for susceptibility to complex diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

On the allelic spectrum of human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

The future of genetic studies of complex human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Replication of linkage studies of complex traits: an examination of variation in location estimates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Pharmacogenetics and the practice of medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A genomic-systems biology map for cardiovascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A statistical method for identification of polymorphisms that explain a linkage result

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Maturity Onset-type Diabetes of the Young (MODY): One Condition or Many?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A biological atlas of functional maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Linkage disequilibrium and the mapping of complex human traits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Global and societal implications of the diabetes epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

An Automated Fluorescent Single-Strand Conformation Polymorphism Technique for Screening Mutations in the Hepatocyte Nuclear Factor-1α Gene (Maturity-Onset Diabetes of the Young)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Mutation screening in 18 Caucasian families suggest the existence of other MODY genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00099.2002

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

21 January 2018

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/47254

10.1152/AJPENDO.00099.2002

15 July 2023

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12110525