Asthma -- a need for a rethink? (Q34740896)

4 August 2017

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title

Asthma -- a need for a rethink? (English)

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4 August 2017

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Domenico Spina

1

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author name string

Clive P Page

series ordinal

2

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4 August 2017

1 July 2002

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Trends in Pharmacological Sciences

4 August 2017

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4 August 2017

23

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4 August 2017

7

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4 August 2017

311-315

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Treatment of asthma with drugs modifying the leukotriene pathway.

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The effect of GR32191 (a thromboxane receptor antagonist) on airway responsiveness in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Differential regulation of evoked peptide release by voltage-sensitive calcium channels in rat sensory neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

PAF and asthma--time for an appraisal?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Eosinophilic Inflammation in Asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Development of a monoclonal anti-immunoglobulin E antibody (omalizumab) for the treatment of allergic respiratory disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.

1 reference

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

1 reference

7 January 2021

The platelet in asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

TH1 and TH2 CD4+ cells in human allergic diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The relationship between inflammation and hyperreactivity of the airways in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Fatal and near-fatal asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effect of capsaicin on PAF-induced bronchial hyperresponsiveness and pulmonary cell accumulation in the rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on PAF-induced airway responses in neonatally immunized rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Capsaicin pre-treatment prevents the development of antigen-induced airway hyperresponsiveness in neonatally immunised rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The effect of 15-HPETE on airway responsiveness and pulmonary cell recruitment in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Dissociation of airway responsiveness and bronchoalveolar lavage (BAL) cell composition in sensitized guinea-pigs after daily inhalation of ovalbumin

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Ovalbumin challenge following immunization elicits recruitment of eosinophils but not bronchial hyperresponsiveness in guinea-pigs: time course and relationship to eosinophil activation status

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Increased airway reactivity in the guinea-pig follows exposure to intravenous isoprenaline.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The role of sensory nerves in propranolol-induced bronchial hyperresponsiveness in the guinea-pig

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Role of substance P and neurokinin A in toluene diisocyanate-induced increased airway responsiveness in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Modulation of sensory nerve function in the airways

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Enkephalinase Inhibitor Potentiates Substance P- and Capsaicin-induced Bronchial Smooth Muscle Contractions in Humans

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effects of inhaled capsaicin in heart-lung transplant patients and asthmatic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The NK-2 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Relationship of airway responsiveness with airway morphometry in normal and immunized rabbits.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1 reference

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7 January 2021

Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells

1 reference

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7 January 2021

New drug discovery techniques are not so revolutionary

1 reference

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7 January 2021

In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effect of antagonists for NK(2)and B(2) receptors on antigen-induced airway responses in allergic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

A revolution in drug discovery. Combinatorial chemistry still needs logic to drive science forward

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effect of heparin on antigen-induced airway responses and pulmonary leukocyte accumulation in neonatally immunized rabbits.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The effect of neonatal capsaicin on the development of bronchial hyperresponsiveness in allergic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

TRFK-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Interleukin-13: central mediator of allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Enhancement of the bronchial reactivity in immunized rats by neonatal treatment with capsaicin

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effects of capsaicin on the airway responses to inhaled endotoxin in the guinea pig.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Role of tachykinins in ozone-induced acute lung injury in guinea pigs.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

An important role of tachykinins in ozone-induced airway hyperresponsiveness

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Role of C fibers in physiological responses to ozone in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Role of sensory neuropeptides in PIV-3-infection-induced airway hyperresponsiveness in guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Activation of capsaicin-sensitive sensory fibers modulates PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Cationic protein-induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The response of laryngeal afferent fibres to mechanical and chemical stimuli.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effects of vagal and carotid chemoreceptor afferents on the frequency and pattern of spontaneous augmented breaths in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Vagal afferent and reflex responses to changes in surface osmolarity in lower airways of dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Sensory receptor activation by mediators of defense reflexes in guinea-pig lungs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Substance P contributes to rapidly adapting receptor responses to pulmonary venous congestion in rabbits.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

A comparative study of irritant and type J receptors in the cat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Effects of aerosol-applied capsaicin, histamine and prostaglandin E2 on airway sensory receptors of anaesthetized cats.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Actions of moguisteine on cough and pulmonary rapidly adapting receptor activity in the guinea pig.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

The action of sodium cromoglycate on 'C' fibre endings in the dog lung

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Nedocromil sodium and sensory nerves in the dog lung

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Activation of pulmonary C fibres by adenosine in anaesthetized rats: role of adenosine A1 receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

Role of pulmonary C fibers in adenosine-induced respiratory inhibition in anesthetized rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2902022-9

7 January 2021

10.1016/S0165-6147(02)02022-9

Identifiers

DOI

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4 August 2017

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PubMed ID

12119151