Drug and gene targeting to the brain with molecular Trojan horses (Q34742814)

4 August 2017

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title

Drug and gene targeting to the brain with molecular Trojan horses (English)

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4 August 2017

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1

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4 August 2017

publication date

1 February 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

volume

1

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4 August 2017

issue

2

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4 August 2017

page(s)

131-139

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Complex tight junctions of epithelial and of endothelial cells in early foetal brain

4 August 2017

cites work

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Human brain microvascular DR-antigen

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Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?

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Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

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Transport of [125I]transferrin through the rat blood-brain barrier

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Rapid transferrin efflux from brain to blood across the blood-brain barrier

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Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

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Effect of transient focal ischemia on blood-brain barrier permeability in the rat: correlation to cell injury

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Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia

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Neuroprotection with noninvasive neurotrophin delivery to the brain

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Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin

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Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system

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Pharmacology of neurotrophic factors

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Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus

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Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors

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Retention of biologic activity of human epidermal growth factor following conjugation to a blood-brain barrier drug delivery vector via an extended poly(ethylene glycol) linker

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Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease

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Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex

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Abeta(1-40) peptide radiopharmaceuticals for brain amyloid imaging: (111)In chelation, conjugation to poly(ethylene glycol)-biotin linkers, and autoradiography with Alzheimer's disease brain sections.

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Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo

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Antisense and Antigene Properties of Peptide Nucleic Acids

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Antisense imaging of gene expression in the brain in vivo

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Humoral immune responses to adenovirus vectors in the brain

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Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector

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Pharmacokinetics, tissue distribution, and expression efficiency of plasmid [33P]DNA following intravenous administration of DNA/cationic lipid complexes in mice: use of a novel radionuclide approach

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Noninvasive gene targeting to the brain

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Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes

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Kinetic analysis of the initial steps involved in lipoplex--cell interactions: effect of various factors that influence transfection activity.

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Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate

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Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor

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The vascularization of the human cerebellar cortex

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Glut1 glucose transporter activity in human brain injury

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Peptidases, peptides, and the mammalian blood-brain barrier

31 March 2020

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Carrier-mediated or specialized transport of drugs across the blood-brain barrier

31 March 2020

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Receptor-mediated peptide transport through the blood-brain barrier

31 March 2020

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Distribution of nerve growth factor following direct delivery to brain interstitium

31 March 2020

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Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression

31 March 2020

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Morphology of blood-brain interfaces

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

CNS drug design based on principles of blood-brain barrier transport

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD725

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Dimensions Publication ID

4 August 2017

1029297924

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