Central role of peroxisomes in isoprenoid biosynthesis (Q34744687)

4 August 2017

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title

Central role of peroxisomes in isoprenoid biosynthesis (English)

1 reference

4 August 2017

Werner J Kovacs

1

1 reference

PubMed ID

12121718

4 August 2017

Lisa M Olivier

series ordinal

2

1 reference

PubMed ID

12121718

4 August 2017

Skaidrite K Krisans

series ordinal

3

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4 August 2017

1 September 2002

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Progress in Lipid Research

4 August 2017

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4 August 2017

41

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4 August 2017

5

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4 August 2017

369-391

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

3-Hydroxy-3-methylglutaryl coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analyses

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

The peroxisome in retrospect

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Biogenesis of peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Import of peroxisomal matrix and membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Protein translocation machineries of peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Import of proteins into peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Analysis of the carboxyl-terminal peroxisomal targeting signal 1 in a homologous context in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Mutational analysis of the N-terminal topogenic signal of watermelon glyoxysomal malate dehydrogenase using the heterologous host Hansenula polymorpha

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Mutational analyses of a type 2 peroxisomal targeting signal that is capable of directing oligomeric protein import into tobacco BY-2 glyoxysomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

An oligomeric protein is imported into peroxisomes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Oilseed isocitrate lyases lacking their essential type 1 peroxisomal targeting signal are piggybacked to glyoxysomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Import of stably folded proteins into peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Peroxisome biogenesis disorders: genetics and cell biology

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Genotype-phenotype correlations in disorders of peroxisome biogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Lipid metabolism in peroxisomes in relation to human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Fetal cerebrohepatorenal (Zellweger) syndrome: dysmorphic, radiologic, biochemical, and pathologic findings in four affected fetuses.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Phenotype of patients with peroxisomal disorders subdivided into sixteen complementation groups

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Characterization of the hydroxymethylglutaryl-CoA lyase precursor, a protein targeted to peroxisomes and mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Δ3,5-Δ2,4-Dienoyl-CoA Isomerase from Rat Liver

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Characterization of UT2 cells. The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Purification of brain peroxisomes and localization of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

A novel family of longer chain length dolichols present in oleate-induced yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Arabidopsis thaliana contains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Regulation of the mevalonate pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Normalization and subtraction: two approaches to facilitate gene discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Nucleotide sequence of a rat liver cDNA encoding the cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Synergistic activation of transcription by the mutant and wild-type minimal transcriptional activation domain of VP16.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Purification of rat liver mevalonate pyrophosphate decarboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Subcellular localization of squalene synthase in human hepatoma cell line Hep G2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cell compartmentalization of cholesterol biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Peroxisomal cholesterol synthesis in vivo: accumulation of 4-methyl intermediate sterols after aminotriazole inhibition of cholesterol synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Acyl-CoA:dihydroxyacetonephosphate acyltransferase: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Infantile phytanic acid storage disease, a possible variant of Refsum's disease: three cases, including ultrastructural studies of the liver

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Infantile Refsum disease: an inherited peroxisomal disorder. Comparison with Zellweger syndrome and neonatal adrenoleukodystrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Infantile phytanic acid storage disease, a disorder of peroxisome biogenesis: a case report

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Plasma lipoproteins and monocyte‐macrophages in a peroxisome‐deficient system: Study of a patient with infantile refsum disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cholesterol biosynthesis in Zellweger syndrome: normal activity of mevalonate kinase, mevalonate-5'-pyrophosphate decarboxylase and IPP-isomerase in patients' fibroblasts but deficient mevalonate kinase activity in liver

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Normal cholesterol synthesis in human cells requires functional peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cholesterol biosynthesis in dermal fibroblasts from patients with metabolic disorders of peroxisomal origin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cholesterol metabolism in cells with different peroxisomal defects

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Differential deficiency of mevalonate kinase and phosphomevalonate kinase in patients with distinct defects in peroxisome biogenesis: evidence for a major role of peroxisomes in cholesterol biosynthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Increased cholesterol synthesis in Chinese hamster ovary cells deficient in peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Role of cholesterol in embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

The Smith-Lemli-Opitz syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Biochemical and genetic aspects of 7-dehydrocholesterol reductase and Smith-Lemli-Opitz syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Genetic defects in postsqualene cholesterol biosynthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Genetic disorders of cholesterol biosynthesis in mice and humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Mevalonic aciduria: an inborn error of cholesterol biosynthesis?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Near normal levels of isoprenoid lipids in severe mevalonic aciduria

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Decreased plasma ubiquinone-10 concentration in patients with mevalonate kinase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Regulatory adaptation of isoprenoid biosynthesis and the LDL receptor pathway in fibroblasts from patients with mevalonate kinase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

How proteins penetrate peroxisomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Regulation and control in complex, dynamic metabolic systems: experimental application of the top-down approaches of metabolic control analysis to fatty acid oxidation and ketogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Peroxisomal disorders: genotype, phenotype, major neuropathologic lesions, and pathogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cholesterol for synthesis of myelin is made locally, not imported into brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Distinction between peroxisomal bifunctional enzyme and acyl-CoA oxidase deficiencies

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Postnatal development and isolation of peroxisomes from brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Plasmalogens of the nervous system. I. Deposition in developing rat brain and incorporation of C14 isotope from acetate and palmitate into the α,β-unsaturated ether chain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Microperoxisomes in the central nervous system of the postnatal rat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

The desmosterol reductase activity of rat brain during development.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

A mouse model for Zellweger syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Restoration by a 35K membrane protein of peroxisome assembly in a peroxisome-deficient mammalian cell mutant

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cholesterol metabolism and embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Defective forebrain development in mice lacking gp330/megalin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

The LDL receptor gene family: signaling functions during development.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Teratogenic Effect of AY 9944 in Rats: Importance of the Day of Administration and Maternal Plasma Cholesterol Level

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

How cells handle cholesterol.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cholesterol modification of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Cholesterol in signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Caveolae and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Pathogenesis of malformations in a rodent model for Smith-Lemli-Opitz syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Neurosteroids: biosynthesis and function of these novel neuromodulators

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2802%2900002-4

7 January 2021

10.1016/S0163-7827(02)00002-4

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12121718