HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair (Q34746885)

4 August 2017

title

HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair (English)

1 reference

4 August 2017

A S Yang

1

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4 August 2017

J C Shen

2

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4 August 2017

J M Zingg

3

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4 August 2017

S Mi

4

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4 August 2017

P A Jones

5

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4 August 2017

language of work or name

English

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publication date

1 April 1995

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4 August 2017

published in

Nucleic Acids Research

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4 August 2017

volume

23

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4 August 2017

issue

8

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4 August 2017

page(s)

1380-1387

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The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center

4 August 2017

cites work

1 reference

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Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase

7 July 2018

1 reference

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Uracil-DNA glycosylase as a probe for protein--DNA interactions

7 July 2018

1 reference

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HhaI methyltransferase flips its target base out of the DNA helix

7 July 2018

1 reference

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Hypermutability and mismatch repair deficiency in RER+ tumor cells

7 July 2018

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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

7 July 2018

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

7 July 2018

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Incision at DNA G.T mispairs by extracts of mammalian cells occurs preferentially at cytosine methylation sites and is not targeted by a separate G.T binding reaction

7 July 2018

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The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA

7 July 2018

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DNA repair rates mapped along the human PGK1 gene at nucleotide resolution

7 July 2018

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Effect of DNA cytosine methylation upon deamination-induced mutagenesis in a natural target sequence in duplex DNA.

7 July 2018

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Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coli

7 July 2018

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Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

7 July 2018

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7 July 2018

DNA methyltransferases

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M.HhaI binds tightly to substrates containing mismatches at the target base

7 July 2018

1 reference

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High-resolution structure of a DNA helix containing mismatched base pairs.

7 July 2018

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Promoters of Escherichia coli: a hierarchy of in vivo strength indicates alternate structures.

7 July 2018

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DNA cytosine methylation and heat-induced deamination

7 July 2018

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The CpG dinucleotide and human genetic disease

7 July 2018

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5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase

7 July 2018

1 reference

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In vitro correction of G.T mispairs to G.C pairs in nuclear extracts from human cells

7 July 2018

1 reference

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The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model

7 July 2018

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Mutations causing hemophilia B: direct estimate of the underlying rates of spontaneous germ-line transitions, transversions, and deletions in a human gene

7 July 2018

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Recognition of unusual DNA structures by human DNA (cytosine-5)methyltransferase

7 July 2018

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Mismatch repair genes of Streptococcus pneumoniae: HexA confers a mutator phenotype in Escherichia coli by negative complementation

7 July 2018

1 reference

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Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

The sequence specificity domain of cytosine-C5 methylases

7 July 2018

1 reference

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Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase

7 July 2018

1 reference

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Isolation and characterization of the cDNA encoding human DNA methyltransferase

7 July 2018

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Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation

7 July 2018

1 reference

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Generation of single-nucleotide repair patches following excision of uracil residues from DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

Methylation, mutation and cancer

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

Sequence-specific DNA binding by the MspI DNA methyltransferase

7 July 2018

1 reference

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High frequency mutagenesis by a DNA methyltransferase

7 July 2018

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Asn177 in Escherichia coli thymidylate synthase is a major determinant of pyrimidine specificity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

Substitutions of a cysteine conserved among DNA cytosine methylases result in a variety of phenotypes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

Molecular basis of base substitution hotspots in Escherichia coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306865

DNA methylation and cancer

26 October 2018

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12 December 2020

Heat-induced deamination of cytosine residues in deoxyribonucleic acid

1 reference

12 December 2020

Kinetic and catalytic mechanism of HhaI methyltransferase

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12 December 2020

A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine

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12 December 2020

Frequency of abnormal human haemoglobins caused by C----T transitions in CpG dinucleotides

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12 December 2020

Identifiers

DOI

10.1093/NAR/23.8.1380

1 reference

4 August 2017

1 reference

4 August 2017

1 reference