Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. (Q34747269)

4 August 2017

title

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. (English)

1 reference

4 August 2017

1 reference

16

Timothy A J Haystead

1 reference

4 August 2017

Matthew K Howe

1

1 reference

4 August 2017

Khaldon Bodoor

2

1 reference

4 August 2017

David A Carlson

3

1 reference

4 August 2017

Philip F Hughes

4

1 reference

4 August 2017

Yazan Alwarawrah

5

1 reference

4 August 2017

David R Loiselle

6

1 reference

4 August 2017

Alex M Jaeger

7

1 reference

4 August 2017

David B Darr

8

1 reference

4 August 2017

Jamie L Jordan

9

1 reference

4 August 2017

Lucas M Hunter

10

1 reference

4 August 2017

Eileen T Molzberger

11

1 reference

4 August 2017

Theodore A Gobillot

12

1 reference

4 August 2017

Dennis J Thiele

13

1 reference

4 August 2017

Jeffrey L Brodsky

14

1 reference

4 August 2017

Neil L Spector

15

1 reference

4 August 2017

publication date

11 December 2014

1 reference

4 August 2017

published in

Chemistry and Biology

1 reference

4 August 2017

volume

21

1 reference

4 August 2017

issue

12

1 reference

4 August 2017

page(s)

1648-1659

1 reference

Functional analysis of Hsp70 inhibitors

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Inhibition of HSP70: a challenging anti-cancer strategy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

HSP70s: From Tumor Transformation to Cancer Therapy.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Heat shock protein 70 (hsp70) as an emerging drug target.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

A small molecule inhibitor of inducible heat shock protein 70.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Death by chaperone: HSP90, HSP70 or both?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Design of a fluorescence polarization assay platform for the study of human Hsp70

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Identification of small molecules that modify the protein folding activity of heat shock protein 70.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Universal screening methods and applications of ThermoFluor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Hsp70 chaperones: cellular functions and molecular mechanism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Stressed to death: regulation of apoptotic signaling pathways by the heat shock proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

A hitchhiker's guide to the human Hsp70 family

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Fast docking using the CHARMM force field with EADock DSS.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

ATPases as drug targets: insights from heat shock proteins 70 and 90.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Hsp70 dynamics in vivo: effect of heat shock and protein aggregation.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272656

A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT 077

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25500222

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2014.10.016

1 reference

release_u7usxlf7nzcqnjkei64vsgqska

4 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/u7usxlf7nzcqnjkei64vsgqska

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4272656

1 reference

4 August 2017

1 reference