Large shifts in pKa values of lysine residues buried inside a protein (Q34750136)

4 August 2017

Large shifts in pKa values of lysine residues buried inside a protein (English)

1 reference

4 August 2017

Daniel G Isom

1

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4 August 2017

Carlos A Castañeda

series ordinal

2

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4 August 2017

Brian R Cannon

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3

1 reference

4 August 2017

Bertrand García-Moreno

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4

1 reference

4 August 2017

language of work or name

English

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publication date

9 March 2011

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Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

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4 August 2017

108

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4 August 2017

5260-5265

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4 August 2017

13

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Structural origins of high apparent dielectric constants experienced by ionizable groups in the hydrophobic core of a protein

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Charges in the hydrophobic interior of proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Conformational consequences of ionization of Lys, Asp, and Glu buried at position 66 in staphylococcal nuclease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Protein vivisection reveals elusive intermediates in folding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Molecular determinants of the pKa values of Asp and Glu residues in staphylococcal nuclease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

The origin of the electrostatic perturbation in acetoacetate decarboxylase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

The pKa Values of Acidic and Basic Residues Buried at the Same Internal Location in a Protein Are Governed by Different Factors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Random walk in orthogonal space to achieve efficient free-energy simulation of complex systems

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

High tolerance for ionizable residues in the hydrophobic interior of proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Influence of nonlinear electrostatics on transfer energies between liquid phases: charge burial is far less expensive than Born model.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

pKa of residue 66 in Staphylococal nuclease. I. Insights from QM/MM simulations with conventional sampling.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

A buried lysine that titrates with a normal pKa: Role of conformational flexibility at the protein-water interface as a determinant of pKavalues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Crystallographic Study of Hydration of an Internal Cavity in Engineered Proteins with Buried Polar or Ionizable Groups

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Role of flexibility and polarity as determinants of the hydration of internal cavities and pockets in proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

High Apparent Dielectric Constant Inside a Protein Reflects Structural Reorganization Coupled to the Ionization of an Internal Asp

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Molecular dynamics study of water penetration in staphylococcal nuclease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Experimental pK(a) values of buried residues: analysis with continuum methods and role of water penetration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

What are the dielectric "constants" of proteins and how to validate electrostatic models?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

High apparent dielectric constants in the interior of a protein reflect water penetration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Structural changes linked to proton translocation by subunit c of the ATP synthase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Electrostatic interactions in wild-type and mutant recombinant human myoglobins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Experimental measurement of the effective dielectric in the hydrophobic core of a protein.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1010750108

Using a charging coordinate in studies of ionization induced partial unfolding

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1010750108

X-ray and thermodynamic studies of staphylococcal nuclease variants I92E and I92K: insights into polarity of the protein interior

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

Dielectric studies of protein hydration and hydration-induced flexibility

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069169

In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core

26 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1010750108

Hydrogen bonding markedly reduces the pK of buried carboxyl groups in proteins

21 January 2018

1 reference

12 December 2020

pH dependence of stability of staphylococcal nuclease: evidence of substantial electrostatic interactions in the denatured state

1 reference

12 December 2020

Dielectric studies of the binding of water to lysozyme

1 reference

12 December 2020

Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation

1 reference

12 December 2020

Effects of buried ionizable amino acids on the reduction potential of recombinant myoglobin

1 reference

12 December 2020

Role of arginine-38 in regulation of the cytochrome c oxidation-reduction equilibrium

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1010750108

1 reference

4 August 2017

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1 reference

4 August 2017

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