A view to a kill: ligands for Bcl-2 family proteins (Q34754656)

4 August 2017

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title

A view to a kill: ligands for Bcl-2 family proteins (English)

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4 August 2017

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3

Alanna Schepartz

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4 August 2017

Stacey E Rutledge

1

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4 August 2017

Jason W Chin

series ordinal

2

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4 August 2017

publication date

1 August 2002

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Current Opinion in Chemical Biology

4 August 2017

published in

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4 August 2017

volume

6

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4 August 2017

issue

4

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4 August 2017

page(s)

479-485

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Programmed cell death: alive and well in the new millennium

4 August 2017

cites work

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A matter of life and death

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Apoptosis and tumourigenesis

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7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

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Signaling pathways in apoptosis as potential targets for cancer therapy

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Apoptosis-regulating proteins as targets for drug discovery

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7 January 2021

From bench to clinic with apoptosis-based therapeutic agents

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7 January 2021

Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis

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7 January 2021

Life-or-death decisions by the Bcl-2 protein family.

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7 January 2021

The Bcl-2 protein family

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7 January 2021

Biochemical pathways of caspase activation during apoptosis

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7 January 2021

Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion

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7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

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7 January 2021

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases

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7 January 2021

Regulation of apoptosis by BH3 domains in a cell-free system

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7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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7 January 2021

Novel anticancer drug discovery

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7 January 2021

Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance

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7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

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7 January 2021

Solution structure of BID, an intracellular amplifier of apoptotic signaling

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7 January 2021

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

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7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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7 January 2021

Solution structure of the antiapoptotic protein bcl-2

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7 January 2021

Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

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7 January 2021

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus

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7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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7 January 2021

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

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7 January 2021

Identification of the in vivo role of a viral bcl-2

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7 January 2021

Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virus

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7 January 2021

The emerging power of chemical genetics

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7 January 2021

Interaction, assembly and processing At the chemistry-biology interface

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7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

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7 January 2021

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

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7 January 2021

A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors

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7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

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7 January 2021

Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A.

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7 January 2021

Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions

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7 January 2021

The atomic structure of protein-protein recognition sites

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7 January 2021

Principles of protein-protein interactions

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7 January 2021

Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

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7 January 2021

Protein transduction technology

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7 January 2021

10.1016/S1367-5931(02)00352-6

Identifiers

DOI

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4 August 2017

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