Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice (Q34768479)

4 August 2017

Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice (English)

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4 August 2017

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H Liu

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4 August 2017

Y Luo

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T Zhang

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Y Zhang

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Q Wu

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L Yuan

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S S M Chung

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P J Oates

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J Y Yang

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language of work or name

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27 January 2011

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54

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5

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1242-1251

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https://scigraph.springernature.com/pub.10.1007/s00125-011-2045-4

4 August 2017

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cites work

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Aldose reductase inhibitors and diabetic kidney disease

7 July 2018

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Aldose reductase genotypes and cardiorenal complications: an 8-year prospective analysis of 1,074 type 2 diabetic patients

7 July 2018

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Oxidative stress as a major culprit in kidney disease in diabetes

7 July 2018

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The role of protein kinase C activation in diabetic nephropathy

7 July 2018

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Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment

7 July 2018

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Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells

7 July 2018

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Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism

7 July 2018

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Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications

7 July 2018

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Aldose reductase in diabetic microvascular complications

7 July 2018

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Relevance of aldo-keto reductase family members to the pathobiology of diabetic nephropathy and renal development

7 July 2018

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Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis

7 July 2018

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Aldose reductase-deficient mice develop nephrogenic diabetes insipidus

7 July 2018

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TGF-beta in diabetic kidney disease: role of novel signaling pathways

7 July 2018

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Identification and characterization of a novel human aldose reductase-like gene

7 July 2018

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Mechanism of human aldehyde reductase: characterization of the active site pocket

7 July 2018

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Sorbitol, osmoregulation, and the complications of diabetes

7 July 2018

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Aldose reductase, glomerular metabolism, and diabetic nephropathy

7 July 2018

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Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.

7 July 2018

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Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats

7 July 2018

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Reduction of glomerular hyperfiltration in normoalbuminuric IDDM patients by 6 mo of aldose reductase inhibition.

7 July 2018

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Enhanced in situ expression of aldose reductase in peripheral nerve and renal glomeruli in diabetic patients

7 July 2018

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Increased urinary type IV collagen marks the development of glomerular pathology in diabetic d/db mice

21 January 2018

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Glucose-mediated induction of TGF-beta 1 and MCP-1 in mesothelial cells in vitro is osmolality and polyol pathway dependent

21 January 2018

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Analysis of the association between diabetic nephropathy and polymorphisms in the aldose reductase gene in Type 1 and Type 2 diabetes mellitus

21 January 2018

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Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil

21 January 2018

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12 December 2020

The effect of an aldose reductase inhibitor (Epalrestat) on diabetic nephropathy in rats

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12 December 2020

Prevention of early glomerulopathy with tolrestat in the streptozotocin-induced diabetic rat

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12 December 2020

Induction of aldose reductase expression in rat kidney mesangial cells and Chinese hamster ovary cells under hypertonic conditions

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12 December 2020

Interaction between the polyol pathway and non-enzymatic glycation on mesangial cell gene expression

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12 December 2020

Quantitative histochemistry of the sorbitol pathway in glomeruli and small arteries of human diabetic kidney

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12 December 2020

Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA

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12 December 2020

The role of aldose reductase gene in the susceptibility to diabetic nephropathy in Type II (non-insulin-dependent) diabetes mellitus

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12 December 2020

Effect of statil on kidney structure, function and polyol accumulation in diabetes mellitus

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12 December 2020

Zopolrestat prevention of proteinuria, albuminuria and cataractogenesis in diabetes mellitus

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12 December 2020

Aldose reductase inhibition and glomerular abnormalities in diabetic rats

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12 December 2020

Cell and matrix components of the glomerular mesangium in type I diabetes

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12 December 2020

Aldose reductase inhibitors: therapeutic implications for diabetic complications

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12 December 2020

Diabetic nephropathy is not associated with the dinucleotide repeat polymorphism upstream of the aldose reductase (ALR2) gene but with erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes

1 reference

12 December 2020

Association between (AC)n dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and diabetic nephropathy: a meta-analysis

1 reference

12 December 2020

Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy

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12 December 2020

Effect of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent

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12 December 2020

Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type 1 diabetes mellitus

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12 December 2020

Polymorphism in the 5'-End of the Aldose Reductase Gene Is Strongly Associated With the Development of Diabetic Nephropathy in Type I Diabetes

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12 December 2020

Effect of inhibition of aldose reductase on glucose flux, diacylglycerol formation, protein kinase C, and phospholipase A2 activation

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12 December 2020

Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase

1 reference

12 December 2020

Osmotic Stress Induces Aldose Reductase in Glomerular Endothelial Cells

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12 December 2020

Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: effect on urinary albumin excretion

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12 December 2020

Identification and characterization of aldose reductase in cultured rat mesangial cells

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12 December 2020

An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-beta and protein kinase C activity in cultured mesangial cells

1 reference

12 December 2020

10.1007/S00125-011-2045-4

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4 August 2017

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4 August 2017

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