A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer. (Q34768677)

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English	A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer.	scientific article

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16 January 2020

A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer (English)

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16 January 2020

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cervix uterine cancer

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Susan E Bates

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Tito Fojo

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Richard L Piekarz

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Richard L Piekarz

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Ronan J Kelly

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Deborah Draper

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Clara C Chen

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William D Figg

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Xiaohong Chen

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Erin R Gardner

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Aradhana M Venkatesan

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Seth M Steinberg

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16 November 2010

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16 January 2020

Clinical Cancer Research

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569-580

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3

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16 January 2020

Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer

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7 July 2018

Structure-activity relationships of tariquidar analogs as multidrug resistance modulators

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7 July 2018

P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin

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7 July 2018

Cost-effectiveness of 99mTc-sestamibi in predicting response to chemotherapy in patients with lung cancer: systematic review and meta-analysis

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7 July 2018

Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).

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7 July 2018

Pharmacological strategies for overcoming multidrug resistance

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7 July 2018

Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma

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7 July 2018

The Role of ABC Transporters in Clinical Practice

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7 July 2018

Tetrofosmin as predictors of tumour response

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7 July 2018

Phase I and pharmacokinetic study of escalating dose of docetaxel administered with granulocyte colony-stimulating factor support in adult advanced solid tumors.

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7 July 2018

Multidrug resistance in cancer: role of ATP-dependent transporters

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7 July 2018

In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.

1 reference

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7 July 2018

Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833.

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7 July 2018

Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin

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7 July 2018

p53 and P-glycoprotein expression do not correlate with survival in nonsmall cell lung cancer: a long-term study and literature review

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7 July 2018

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

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7 July 2018

Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP.

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7 July 2018

Evaluation of the linearity of docetaxel pharmacokinetics.

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7 July 2018

Phase II trial of docetaxel: a new, highly effective antineoplastic agent in the management of patients with anthracycline-resistant metastatic breast cancer

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7 July 2018

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

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7 July 2018

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

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7 July 2018

SDZ PSC 833, a non-immunosuppressive cyclosporine: its potency in overcoming P-glycoprotein-mediated multidrug resistance of murine leukemia

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7 July 2018

Expression of MRP1, BCRP, LRP, and ERCC1 in advanced non-small-cell lung cancer: correlation with response to chemotherapy and survival.

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26 October 2018

A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine

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26 October 2018

Epiphora (excessive tearing) and other ocular manifestations related to weekly docetaxel: underestimated dose-limiting toxicity.

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26 October 2018

A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma

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26 October 2018

Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer.

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26 October 2018

Using technetium-99m tetrofosmin chest imaging to predict taxol-based chemotherapy response in non-small cell lung cancer but not related to lung resistance protein expression

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26 October 2018

Predicting chemotherapy response to paclitaxel-based therapy in advanced non-small-cell lung cancer with P-glycoprotein expression.

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26 October 2018

Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576.

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26 October 2018

A phase II study of the MDR inhibitor biricodar (INCEL, VX-710) and paclitaxel in women with advanced ovarian cancer refractory to paclitaxel therapy

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26 October 2018

99mTc-MIBI SPET in non-small cell lung cancer in relationship with Pgp and prognosis

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26 October 2018

Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: a gynecologic oncology group study.

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26 October 2018

Phase I trial of XR9576 in healthy volunteers demonstrates modulation of P-glycoprotein in CD56+ lymphocytes after oral and intravenous administration.

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26 October 2018

Prospective randomized trial of docetaxel versus doxorubicin in patients with metastatic breast cancer.

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26 October 2018

Immunohistochemically detected p53 and P-glycoprotein predict the response to chemotherapy in lung cancer.

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26 October 2018

Docetaxel (Taxotere): an active drug for the treatment of patients with advanced squamous cell carcinoma of the head and neck. EORTC Early Clinical Trials Group.

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26 October 2018

Docetaxel administered on a weekly basis for metastatic breast cancer

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https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

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Comparative study of Tc-99m MIBI and TI-201 SPECT in predicting chemotherapeutic response in non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

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Technetium-99m MIBI single photon emission computed tomography as an indicator of prognosis for patients with lung cancer-preliminaly report

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

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328. Note: The Use of None-Parametric Methods in the Statistical Analysis of the Two-Period Change-Over Design

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

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Semi-quantitative assessment of 99Tcm-sestamibi uptake in lung cancer: relationship with clinical response to chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

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Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of in vivo P-glycoprotein inhibition by PSC 833 using Tc-99m sestamibi

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efflux of rhodamine from CD56+ cells as a surrogate marker for reversal of P-glycoprotein-mediated drug efflux by PSC 833

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

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99mTc-Sestamibi scanning with SDZ PSC 833 as a functional detection method for resistance modulation in patients with solid tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

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Multidrug resistance proteins do not predict benefit of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: International Adjuvant Lung Cancer Trial Biologic Program

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081657

12 December 2020

based on heuristic

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10.1158/1078-0432.CCR-10-1725

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16 January 2020

1 reference

Europe PubMed Central

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16 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21081657%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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