Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule (Q34769867)

4 August 2017

title

Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule (English)

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amyotrophic lateral sclerosis

4 August 2017

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9

Xavier Navarro

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Clara Penas

object named as

Clara Penas

7

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Renzo Mancuso

object named as

Renzo Mancuso

3

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Ana C. Calvo

object named as

Ana C Calvo

1

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author name string

María Moreno-Igoa

2

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4 August 2017

Raquel Manzano

4

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4 August 2017

Sara Oliván

5

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4 August 2017

María J Muñoz

6

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4 August 2017

Pilar Zaragoza

8

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4 August 2017

Rosario Osta

10

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4 August 2017

publication date

21 March 2011

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Orphanet Journal of Rare Diseases

4 August 2017

published in

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4 August 2017

volume

6

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4 August 2017

page(s)

10

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Guidelines for preclinical animal research in ALS/MND: A consensus meeting

4 August 2017

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7 July 2018

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Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

7 July 2018

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IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice

7 July 2018

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Cytoskeletal and activity-related changes in spinal motoneurons after root avulsion

7 July 2018

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A genetic fusion GDNF-C fragment of tetanus toxin prolongs survival in a symptomatic mouse ALS model.

7 July 2018

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Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

7 July 2018

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A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice

7 July 2018

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7 July 2018

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A novel peptide defined through phage display for therapeutic protein and vector neuronal targeting

7 July 2018

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Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

7 July 2018

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7 July 2018

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C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons

7 July 2018

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Programmed cell death in amyotrophic lateral sclerosis

7 July 2018

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

7 July 2018

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HC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transduction

7 July 2018

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BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA(A) receptor surface expression

7 July 2018

1 reference

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Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

7 July 2018

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Construction of hybrid proteins that migrate retrogradely and transynaptically into the central nervous system

7 July 2018

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

7 July 2018

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7 July 2018

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Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

7 July 2018

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An antigenic polypeptide fragment isolated from tetanus toxin: chemical characterization, binding to gangliosides and retrograde axonal transport in various neuron systems

7 July 2018

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Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction

7 July 2018

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A non-viral vector for targeting gene therapy to motoneurons in the CNS.

21 January 2018

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Fragment C of tetanus toxin, more than a carrier. Novel perspectives in non-viral ALS gene therapy

21 January 2018

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Brain-derived neurotrophic factor facilitates in vivo internalization of tetanus neurotoxin C-terminal fragment fusion proteins in mature mouse motor nerve terminals.

21 January 2018

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Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF.

21 January 2018

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FK506 enhances regeneration of axons across long peripheral nerve gaps repaired with collagen guides seeded with allogeneic Schwann cells

21 January 2018

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Spatial-temporal patterns of gene expression in mouse skeletal muscle after injection of lacZ plasmid DNA.

21 January 2018

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The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways

21 January 2018

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2000 Report of the AVMA Panel on Euthanasia

21 January 2018

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12 December 2020

Assessing disease onset and progression in the SOD1 mouse model of ALS

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12 December 2020

Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease

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12 December 2020

Genetics of amyotrophic lateral sclerosis

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12 December 2020

A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

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12 December 2020

Interaction of tetanus toxin derived hybrid proteins with neuronal cells

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12 December 2020

Identifiers

DOI

10.1186/1750-1172-6-10

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Dimensions Publication ID

4 August 2017

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1 reference

4 August 2017

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