DNA methylation in cancer: too much, but also too little (Q34770545)

4 August 2017

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title

DNA methylation in cancer: too much, but also too little (English)

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4 August 2017

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Melanie Ehrlich

1

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PubMed ID

12154403

4 August 2017

language of work or name

English

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publication date

1 August 2002

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4 August 2017

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4 August 2017

21

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4 August 2017

5400-5413

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4 August 2017

35

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205651

4 August 2017

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cites work

DNA hypomethylation in breast cancer: an independent parameter of tumor progression?

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7 January 2021

Break points in chromosome #1 abnormalities of 218 human neoplasms.

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7 January 2021

The tumorigenicity of 5-azacytidine in the male Fischer rat.

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7 January 2021

Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Cell lineage-specific undermethylation of mouse repetitive DNA

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

DNA hypomethylation leads to elevated mutation rates

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Global methylation profiling of lung cancer identifies novel methylated genes

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

5-azacytidine potentiates initiation induced by carcinogens in rat liver

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Expression of intracisternal A-particle retrotransposons in primary tumors of oncogene-expressing transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

MethyLight: a high-throughput assay to measure DNA methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

A new moderately repetitive DNA sequence family of novel organization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypomethylation of ras oncogenes in primary human cancers

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Nuclear relocation of a transactivator subunit precedes target gene activation.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Tissue-specific differences in DNA methylation in various mammals.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

The 5-methylcytosine content of DNA from human tumors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Repeat-induced gene silencing in mammals.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypomethylation of DNA from benign and malignant human colon neoplasms

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Regulation of human endogenous retrovirus-K Gag expression in teratocarcinoma cell lines and human tumours

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypermethylation of calcitonin gene regulatory sequences in human breast cancer as revealed by genomic sequencing

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Preferential induction of chromosome 1 multibranched figures and whole-arm deletions in a human pro-B cell line treated with 5-azacytidine or 5-azadeoxycytidine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

DNA demethylation and pericentromeric rearrangements of chromosome 1.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

The impact of L1 retrotransposons on the human genome

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Genomic distribution and transcription of solitary HERV-K LTRs

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

LAGE-1, a new gene with tumor specificity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Role for DNA methylation in genomic imprinting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

DNA hypomethylation in Morris hepatomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Epigenetic gene deregulation in cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Involvement of DNA methylation in the control of the expression of an estrogen-induced breast-cancer-associated protein (pS2) in human breast cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Negative regulation of human immune deficiency virus replication in monocytes. Distinctions between restricted and latent expression in THP-1 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

alpha-satellite DNA methylation in normal individuals and in ICF patients: heterogeneous methylation of constitutive heterochromatin in adult and fetal tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Epigenetic inheritance at the agouti locus in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypomethylation of pericentromeric DNA in breast adenocarcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Chromosome heterozygosity and de novo chromosome rearrangements in mammalian interspecies hybrids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Active demethylation of the paternal genome in the mouse zygote

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Methyl group deficiency in hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Human breast and colon cancers exhibit alterations of DNA methylation patterns at several DNA segments on chromosomes 11p and 17p

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

A deletion polymorphism due to Alu-Alu recombination in intron 2 of the retinoblastoma gene: association with human gliomas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Alu repeated DNAs are differentially methylated in primate germ cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

High frequency of alterations in DNA methylation in adenocarcinoma of the prostate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Mechanisms of Igf2/H19 imprinting: DNA methylation, chromatin and long-distance gene regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Many human L1 elements are capable of retrotransposition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Genomic imprinting and cancer; new paradigms in the genetics of neoplasia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Methylated CpG points identified within MAGE-1 promoter are involved in gene repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Patterns of methylation of the c-myc gene in human colorectal cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Alteration of mosaic methylation of the repeat unit of the human ribosomal RNA genes in lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Global DNA hypomethylation in breast carcinoma: correlation with prognostic factors and tumor progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Relaxation of IGF2 imprinting in Wilms tumours associated with specific changes in IGF2 methylation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Analysis of methylation patterns in the regulatory region of the latent Epstein-Barr virus promoter BCR2 by automated fluorescent genomic sequencing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Production of thyroid tumours in mice by demethylating agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

A methylated human 9-kb repetitive sequence on acrocentric chromosomes is homologous to a subtelomeric repeat in chimpanzees

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Demethylation of repetitive DNA sequences in neuroblastoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

DNA hypomethylation and unusual chromosome instability in cell lines from ICF syndrome patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Transcription of IAP endogenous retroviruses is constrained by cytosine methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Human L1 retrotransposition: cis preference versus trans complementation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Retrotransposons as epigenetic mediators of phenotypic variation in mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypermethylation of ribosomal DNA in human breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Hypermethylation of human DNA sequences in embryonal carcinoma cells and somatic tissues but not in sperm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Human DNA sequences exhibiting gamete-specific hypomethylation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205651

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205651

1 reference

PubMed ID

12154403

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12154403