The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive (Q34773789)

4 August 2017

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title

The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive (English)

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4 August 2017

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Arindam Dhar

1

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4 August 2017

Mathew R Young

series ordinal

2

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4 August 2017

Nancy H Colburn

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3

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4 August 2017

publication date

1 May 2002

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Molecular and Cellular Biochemistry

4 August 2017

published in

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4 August 2017

volume

234-235

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4 August 2017

issue

1-2

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4 August 2017

page(s)

185-193

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Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells

4 August 2017

cites work

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12 December 2020

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins

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12 December 2020

Oxygen-reactive species and antioxidant responses during development: the metabolic paradox of cellular differentiation

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12 December 2020

Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation

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12 December 2020

Low levels of reactive oxygen species as modulators of cell function

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12 December 2020

The role of the cellular antioxidant defense in oxidant carcinogenesis

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12 December 2020

Lack of suppression of tumor cell phenotype by overexpression of TIMP-3 in mouse JB6 tumor cells identification of a transfectant with increased tumorigenicity and invasiveness.

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12 December 2020

Induced expression of dominant-negative c-jun downregulates NFkappaB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes

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12 December 2020

Roles of vitamin C in radiation-induced DNA damage in presence and absence of copper

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12 December 2020

Inhibition of activator protein 1 activity and neoplastic transformation by aspirin

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12 December 2020

Molecular cloning of a tumor promoter-inducible mRNA found in JB6 mouse epidermal cells: induction is stable at high, but not at low, cell densities

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12 December 2020

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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12 December 2020

Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation

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12 December 2020

Reactive oxygen species production of neutrophils in patients with acute promyelocytic leukemia during treatment with all-trans retinoic acid

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12 December 2020

Differential c-jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformation

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12 December 2020

Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB.

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12 December 2020

The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells

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12 December 2020

HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors

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12 December 2020

Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA.

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12 December 2020

A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L

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12 December 2020

Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model.

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12 December 2020

Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element.

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12 December 2020

1 alpha,25-Dihydroxyvitamin D3 enhances 12-O-tetradecanoylphorbol-13-acetate- induced tumorigenic transformation and osteopontin expression in mouse JB6 epidermal cells.

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12 December 2020

Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different procedures

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12 December 2020

Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization

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12 December 2020

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

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12 December 2020

c-jun and multistage carcinogenesis: association of overexpression of introduced c-jun with progression toward a neoplastic endpoint in mouse JB6 cells sensitive to tumor promoter-induced transformation

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12 December 2020

Vanadate-induced activation of activator protein-1: role of reactive oxygen species

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12 December 2020

Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells

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12 December 2020

Genes that cooperate with tumor promoters in transformation

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12 December 2020

Gene regulation by reactive oxygen species

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12 December 2020

High mobility group-I(Y) protein facilitates nuclear factor-kappaB binding and transactivation of the inducible nitric-oxide synthase promoter/enhancer

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12 December 2020

Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB

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12 December 2020

Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.

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12 December 2020

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

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12 December 2020

AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells.

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12 December 2020

Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells

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12 December 2020

Responses of preneoplastic epidermal cells to tumor promoters and growth factors: use of promoter-resistant variants for mechanism studies.

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12 December 2020

Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-kappaB activation

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12 December 2020

cDNA cloning and mapping of mouse pleckstrin (Plek), a gene upregulated in transformation-resistant cells

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12 December 2020

Redox regulation of genes that protect against carcinogens

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12 December 2020

Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea.

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12 December 2020

Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells

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12 December 2020

Phorbol diester and epidermal growth factor receptors in 12-O-tetradecanoylphorbol-13-acetate-resistant and -sensitive mouse epidermal cells

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12 December 2020

Tumor promotion resistant cells are deficient in AP-1 DNA binding, JunD DNA binding and JunD expression and form different AP-1-DNA complexes than promotion sensitive cells

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12 December 2020

Preferential primary-response gene expression in promotion-resistant versus promotion-sensitive JB6 cells

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12 December 2020

Constitutive and phorbol-myristate-acetate regulated antioxidant defense of mouse epidermal JB6 cells

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12 December 2020

Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 and its promoter. Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation

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12 December 2020

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

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12 December 2020

Glutathione peroxidase compensates for the hypersensitivity of Cu,Zn-superoxide dismutase overproducers to oxidant stress

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12 December 2020

12-O-tetradecanoylphorbol-13-acetate--induced levels of AP-1 proteins: a 46-kDa protein immunoprecipitated by anti-fra-1 and induced in promotion-resistant but not promotion-sensitive JB6 cells

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12 December 2020

Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response.

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12 December 2020

Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells

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12 December 2020

Cellular redox state and its relationship to the inhibition of clonal cell growth and the induction of apoptosis during all-trans retinoic acid exposure in acute myeloblastic leukemia cells

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12 December 2020

Expression of dominant negative Jun inhibits elevated AP-1 and NF-kappaB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes

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12 December 2020

Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells

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12 December 2020

Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis

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12 December 2020

The NF-kappa B and I kappa B proteins: new discoveries and insights

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12 December 2020

MAPKs: new JNK expands the group

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12 December 2020

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

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12 December 2020

Ultraviolet radiation and reactive oxygen generation as inducers of keratinocyte apoptosis: protective role of tea polyphenols

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12 December 2020

Pleckstrin homology domains.

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12 December 2020

Transforming JB6 cells exhibit enhanced integrin-mediated adhesion to osteopontin

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12 December 2020

Rel/NF-kappa B and I kappa B factors in oncogenesis

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12 December 2020

Pathophysiological mechanisms of active oxygen

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12 December 2020

Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

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12 December 2020

Regulation of gene expression by reactive oxygen

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12 December 2020

Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells

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12 December 2020

Oxy-radicals and cancer

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12 December 2020

Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation

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12 December 2020

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

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12 December 2020

Glutathione protects a human insulinoma cell line from tumor necrosis factor-alpha-mediated cytotoxicity

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12 December 2020

Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis

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12 December 2020

A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation

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12 December 2020

Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cells

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12 December 2020

The balance between copper-zinc superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress

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12 December 2020

C-JUN/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells

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12 December 2020

Rel/NF-kappaB/IkappaB proteins and cancer

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12 December 2020

Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets

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12 December 2020

Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR mice

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12 December 2020

Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol.

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12 December 2020

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

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12 December 2020

The N-terminal domain of IkappaB alpha masks the nuclear localization signal(s) of p50 and c-Rel homodimers

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12 December 2020

Differential cytotoxicity in mouse epidermal JB6 cells: a potential mechanism for oxidant tumor promotion

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12 December 2020

Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter

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12 December 2020

Cellular thiols and reactive oxygen species in drug-induced apoptosis

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12 December 2020

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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12 December 2020

Phorbol ester-induced anchorage independence and its antagonism by retinoic acid correlates with altered expression of specific glycoproteins

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12 December 2020

A family of mitogen-activated protein kinase-related proteins interacts in vivo with activator protein-1 transcription factor.

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12 December 2020

Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3.

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12 December 2020

Oxidative stress and gene regulation

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12 December 2020

Specific methylation events contribute to the transcriptional repression of the mouse tissue inhibitor of metalloproteinases-3 gene in neoplastic cells

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12 December 2020

Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation

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12 December 2020

Inhibition of AP-1 and NF-kappaB by manganese-containing superoxide dismutase in human breast cancer cells.

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12 December 2020

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression

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12 December 2020

Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha.

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12 December 2020

Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression

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12 December 2020

Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3.

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12 December 2020

Tumour promoter induces anchorage independence irreversibly

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12 December 2020

Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.

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12 December 2020

Identification of high mobility group protein I(Y) as potential progression marker for prostate cancer by differential hybridization analysis

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12 December 2020

UV induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal C1 41 cells through hydrogen peroxide

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12 December 2020

Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase

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12 December 2020

Promotion-sensitive epidermal and mammary epithelial cells maintained in suspension over agarose.

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12 December 2020

The stress-activated protein kinase subfamily of c-Jun kinases

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12 December 2020

Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells

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12 December 2020

Tumor promoter-induced ornithine decarboxylase gene expression occurs independently of AP-1 activation.

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12 December 2020

Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

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12 December 2020

Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase.

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12 December 2020

Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not -resistant cells

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12 December 2020

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis.

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12 December 2020

Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid

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12 December 2020

Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.

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12 December 2020

A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytes

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12 December 2020

Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-kappaB.

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12 December 2020

Effects of food factors on signal transduction pathways.

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12 December 2020

Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently

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12 December 2020

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum

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12 December 2020

Regulation and properties of extracellular signal-regulated protein kinases 1, 2, and 3

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12 December 2020

Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer

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12 December 2020

Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells

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12 December 2020

Identifiers

DOI

10.1023/A:1015948505117

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Dimensions Publication ID

4 August 2017

1047033733

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