Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production (Q34779126)

4 August 2017

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production (English)

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4 August 2017

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Benedikt Engels

1

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PubMed ID

18485776

4 August 2017

Pia Dahm

series ordinal

2

1 reference

PubMed ID

18485776

4 August 2017

Stefan Jennewein

series ordinal

3

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4 August 2017

26 March 2008

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4 August 2017

Metabolic Engineering

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4 August 2017

10

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4 August 2017

3-4

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4 August 2017

201-206

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Anaerobic nutrition of Saccharomyces cerevisiae. I. Ergosterol requirement for growth in a defined medium

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2008.03.001

7 January 2021

The taxane diterpenoids

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https://api.crossref.org/works/10.1016%2FJ.YMBEN.2008.03.001

Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

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1 reference

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Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms.

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1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2008.03.001

Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae

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Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2008.03.001

Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2008.03.001

Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol production

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1 reference

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The shape of things to come: structural and synthetic studies of taxol and related compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2008.03.001

Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew

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1 reference

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Pleiotropic mutations in Saccharomyces cerevisiae affecting sterol uptake and metabolism

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1 reference

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Involvement of heme components in sterol metabolism ofSaccharomyces cerevisiae

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1 reference

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Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis

7 January 2021

1 reference

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Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2008.03.001

Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew

7 January 2021

1 reference

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

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1 reference

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Glyceraldehyde-3-phosphate dehydrogenase-derived expression cassettes for constitutive synthesis of heterologous proteins

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1 reference

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Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast

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1 reference

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Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.

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1 reference

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An interlaboratory comparison of physiological and genetic properties of four Saccharomyces cerevisiae strains

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1 reference

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Construction of a set of Saccharomyces cerevisiae vectors designed for recombinational cloning.

7 January 2021

1 reference

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Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae

7 January 2021

1 reference

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7 January 2021

Taxol biosynthetic genes

1 reference

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Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells

7 January 2021

1 reference

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Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction

7 January 2021

1 reference

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A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis

7 January 2021

1 reference

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Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2008.03.001

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.YMBEN.2008.03.001

1 reference

4 August 2017

1 reference

PubMed ID

18485776