Natural products to drugs: natural product-derived compounds in clinical trials (Q34780898)

4 August 2017

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title

Natural products to drugs: natural product-derived compounds in clinical trials (English)

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4 August 2017

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Mark S Butler

1

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publication date

7 May 2008

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4 August 2017

Natural Product Reports

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4 August 2017

25

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4 August 2017

3

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4 August 2017

475-516

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Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties

4 August 2017

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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 January 2018

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Incretins and their role in the management of diabetes

21 January 2018

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SM-216601, a novel parenteral 1beta-methylcarbapenem: structure-activity relationships of antibacterial activity and neurotoxicity in mice

21 January 2018

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In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic

21 January 2018

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21 January 2018

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Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424).

21 January 2018

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Conversion of viramidine to ribavirin in vivo by adenosine deaminase and its inhibition by 2'-deoxycoformycin.

21 January 2018

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Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C.

21 January 2018

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Iminosugars as possible broad spectrum anti hepatitis virus agents: the glucovirs and alkovirs

21 January 2018

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Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives

21 January 2018

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The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

21 January 2018

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Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols

21 January 2018

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The proteolytic action of Arvin on human fibrinogen

21 January 2018

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A novel combretastatin A-4 derivative, AC-7700, shows marked antitumor activity against advanced solid tumors and orthotopically transplanted tumors.

21 January 2018

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Antitumor activity of noscapine in human non-small cell lung cancer xenograft model

21 January 2018

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Recent advances in the new generation taxane anticancer agents.

21 January 2018

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Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate

21 January 2018

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Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening

21 January 2018

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Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

21 January 2018

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Identification of an antimalarial synthetic trioxolane drug development candidate

21 January 2018

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COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE02779

Halichondrins - antitumor polyether macrolides from a marine sponge

15 July 2023

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC198658050701

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

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9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/ANIE.199615671

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/ANIE.200390115

Friulimicins. Novel Lipopeptide Antibiotics with Peptidoglycan Synthesis Inhibiting Activity from Actinoplanes friuliensis sp. nov. II. Isolation and Structural Characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.816

Friulimicins: novel lipopeptide antibiotics with peptidoglycan synthesis inhibiting activity from Actinoplanes friuliensis sp. nov. I. Taxonomic studies of the producing microorganism and fermentation

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.807

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.49.560

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.47.301

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.47.208

(-)-Phenylahistin arrests cells in mitosis by inhibiting tubulin polymerization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.52.134

Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.44.117

Novel cholecystokinin antagonists from Aspergillus alliaceus. II. Structure determination of asperlicins B, C, D, and E

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.41.878

Novel cholecystokinin antagonists from Aspergillus alliaceus. I. Fermentation, isolation, and biological properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.41.875

The structure of PA48009: The revised structure of duramycin.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.43.1421

A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.37.309

Studies on the differentiation inducers of myeloid leukemic cells. III. Spicamycin, a new inducer of differentiation of HL-60 human promyelocytic leukemia cells

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.36.934

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

A new anti-MRSA antibiotic complex, WAP-8294A. I. Taxonomy, isolation and biological activities.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.51.929

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.571

Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.254

Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.40.575

Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, bilogical and biochemical characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.253

Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.39.1407

The structures of the novel protein kinase C inhibitors K-252a, b, c and d

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.39.1072

K-252a, a potent inhibitor of protein kinase C from microbial origin

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.39.1059

Effect of the Silybin-Phosphatidylcholine Complex (IdB 1016) on the Development of Mammary Tumors in HER-2/neu Transgenic Mice

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1158/0008-5472.CAN-06-2601

Identifiers

DOI

10.1039/B514294F

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4 August 2017

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PubMed ID

18497896