Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation (Q34785746)

4 August 2017

Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation (English)

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4 August 2017

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7

Silvia Priori

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4 August 2017

Augustus O Grant

1

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4 August 2017

Michael P Carboni

2

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4 August 2017

Valentina Neplioueva

3

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4 August 2017

C Frank Starmer

4

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4 August 2017

Mirella Memmi

5

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4 August 2017

Carlo Napolitano

6

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4 August 2017

language of work or name

English

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publication date

1 October 2002

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Journal of Clinical Investigation

4 August 2017

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4 August 2017

110

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4 August 2017

8

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4 August 2017

1201-1209

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Inherited sodium channelopathies: novel therapeutic and proarrhythmic molecular mechanisms

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

A sodium-channel mutation causes isolated cardiac conduction disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Accelerated inactivation in a mutant Na(+) channel associated with idiopathic ventricular fibrillation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Contributions of charged residues in a cytoplasmic linking region to Na channel gating

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Enhanced Na(+) channel intermediate inactivation in Brugada syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Functional suppression of sodium channels by beta(1)-subunits as a molecular mechanism of idiopathic ventricular fibrillation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

A single Na(+) channel mutation causing both long-QT and Brugada syndromes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Cardiac conduction defects associate with mutations in SCN5A

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Solution structure of the sodium channel inactivation gate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Transfer of twelve charges is needed to open skeletal muscle Na+ channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

A molecular link between activation and inactivation of sodium channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Molecular mechanism for an inherited cardiac arrhythmia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Blockade of rabbit atrial sodium channels by lidocaine. Characterization of continuous and frequency-dependent blocking.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Novel mechanism for Brugada syndrome: defective surface localization of an SCN5A mutant (R1432G).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Phenotypic characterization of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium channel.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150793

Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel

26 October 2018

1 reference

12 December 2020

The Elusive Link Between LQT3 and Brugada Syndrome

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12 December 2020

Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes

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12 December 2020

A reinterpretation of mammalian sodium channel gating based on single channel recording

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12 December 2020

Inactivation of Open and Closed Sodium Channels Determined Separately

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12 December 2020

Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase

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12 December 2020

Sodium channel abnormalities are infrequent in patients with long QT syndrome: identification of two novel SCN5A mutations

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12 December 2020

Identifiers

DOI

10.1172/JCI0215570

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4 August 2017

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4 August 2017

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