From cannabis to cannabinergics: new therapeutic opportunities (Q34786818)

4 August 2017

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title

From cannabis to cannabinergics: new therapeutic opportunities (English)

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4 August 2017

Alexandros Makriyannis

series ordinal

2

object named as

Alexandros Makriyannis

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4 August 2017

Andreas Goutopoulos

1

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4 August 2017

1 August 2002

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Pharmacology & Therapeutics

4 August 2017

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4 August 2017

95

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4 August 2017

2

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4 August 2017

103-117

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(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoids control spasticity and tremor in a multiple sclerosis model

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Endocannabinoids control spasticity in a multiple sclerosis model

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Antinociceptive (aminoalkyl)indoles

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Functional role of high-affinity anandamide transport, as revealed by selective inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

The functional neuroanatomy of brain cannabinoid receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Adjuncts to dopamine replacement: a pragmatic approach to reducing the problem of dyskinesia in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Control of pain initiation by endogenous cannabinoids.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Bidirectional control of airway responsiveness by endogenous cannabinoids

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1.

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Neurobiology Cannabinoids act backwards

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Brain cannabinoid systems as targets for the therapy of neurological disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Leptin-regulated endocannabinoids are involved in maintaining food intake

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoid transmission and reward-related events.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Molecular cloning of a human cannabinoid receptor which is also expressed in testis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Dopamine activation of endogenous cannabinoid signaling in dorsal striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Role of cannabinoid receptors in memory storage.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoids, hippocampal function and memory

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoid receptor localization in brain

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Differential receptor-G-protein coupling evoked by dissimilar cannabinoid receptor agonists.

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

The CB1 cannabinoid receptor in the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Signal transduction of eicosanoid CB1 receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Design, Synthesis and Pharmacology of Cannabimimetic Indoles

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Molecular probes for the cannabinoid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Synergistic efects of opioid and cannabinoid antagonists on food intake

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

The molecular basis of cannabinoid activity

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

CB2 cannabinoid receptor-mediated peripheral antinociception

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoid transmission and pain perception

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Discovery and characterization of endogenous cannabinoids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

delta-9-Tetrahydrocannabinol decreases host resistance to herpes simplex virus type 2 vaginal infection in the B6C3F1 mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Molecular characterization of a peripheral receptor for cannabinoids

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Function of cannabinoid receptors in the neuroendocrine regulation of hormone secretion.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Myelin basic protein is an endogenous inhibitor of the high-affinity cannabinoid binding site in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Ligand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Pharmacology of marijuana

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Pharmacology of cannabinoid CB1 and CB2 receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

AM630, a competitive cannabinoid receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Endogenous cannabinoid signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Structural determinants for recognition and translocation by the anandamide transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Motor actions of cannabinoids in the basal ganglia output nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Suppression of human macrophage function in vitro by delta 9-tetrahydrocannabinol

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

A second endogenous cannabinoid that modulates long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Single-dose effects of marihuana smoke. Bronchial dynamics and respiratory-center sensitivity in normal subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Differential effects of delta 9-THC on spatial reference and working memory in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

The neurobiology of cannabinoid analgesia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

Common cannabimimetic pharmacophoric requirements between aminoalkyl indoles and classical cannabinoids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

(Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900250-4

7 January 2021

10.1016/S0163-7258(02)00250-4

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12182958