Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells (Q34792452)

4 August 2017

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells (English)

1 reference

4 August 2017

13

Harold E Varmus

1 reference

4 August 2017

10

Zena Werb

0 references

Mikala Egeblad

8

object named as

Mikala Egeblad

0 references

author name string

Yi Li

1

1 reference

4 August 2017

Bryan Welm

2

1 reference

4 August 2017

Katrina Podsypanina

3

1 reference

4 August 2017

Shixia Huang

4

1 reference

4 August 2017

Mario Chamorro

5

1 reference

4 August 2017

Xiaomei Zhang

6

1 reference

4 August 2017

Tracey Rowlands

7

1 reference

4 August 2017

Pam Cowin

9

1 reference

4 August 2017

Zena Werb

10

1 reference

4 August 2017

Lee K Tan

11

1 reference

4 August 2017

Jeffrey M Rosen

12

1 reference

4 August 2017

language of work or name

English

0 references

publication date

10 December 2003

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

1 reference

4 August 2017

100

1 reference

4 August 2017

15853-15858

1 reference

4 August 2017

26

1 reference

Contribution of stem cells and differentiated cells to epidermal tumours

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Stem-cell hierarchy in skin cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Stem cells in the skin: waste not, Wnt not.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Wnt proteins are lipid-modified and can act as stem cell growth factors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

A role for Wnt signalling in self-renewal of haematopoietic stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Prospective identification of tumorigenic breast cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

WNT signals are required for the initiation of hair follicle development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Initiating oncogenic event determines gene-expression patterns of human breast cancer models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Linking colorectal cancer to Wnt signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Molecular portraits of human breast tumours

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Monoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Purification and characterization of mouse hematopoietic stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Transgenic oncogene mice. Tumor phenotype predicts genotype

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Gene-Expression Profiles in Hereditary Breast Cancer

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2136825100

Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2136825100

Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2136825100

Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2136825100

Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2136825100

neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Whey acidic protein extrinsically expressed from the mouse mammary tumor virus long terminal repeat results in hyperplasia of the coagulation gland epithelium and impaired mammary development.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307657

Reactivity of monoclonal antibodies against intermediate filament proteins during embryonic development

26 October 2018

1 reference

12 December 2020

Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53

1 reference

12 December 2020

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1 reference

12 December 2020

Immunophenotypic properties and estrogen dependency of budding cell structures in the developing mouse mammary gland

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.2136825100

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference