A two-step, two-signal model for the primary activation of precursor helper T cells (Q34797521)

4 August 2017

A two-step, two-signal model for the primary activation of precursor helper T cells (English)

1 reference

4 August 2017

P A Bretscher

1

1 reference

PubMed ID

9874793

4 August 2017

language of work or name

English

0 references

publication date

1 January 1999

1 reference

4 August 2017

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

4 August 2017

96

1 reference

4 August 2017

185-190

1 reference

4 August 2017

1

1 reference

Studies on the transfer of lymph node cells. IV. Effects of X-irradiation of recipient rabbits on the appearance of antibody after cell transfer

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Conditions that induce tolerance in mature CD4+ T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

CD28/B7 system of T cell costimulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Tolerance, danger, and the extended family

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Successful T cell priming in B cell-deficient mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Immunobiology of tissue transplantation: a return to the passenger leukocyte concept

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

T cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Effect of helper T cells on the primary in vitro production of delayed-type hypersensitivity to influenza virus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Tolerance and autoimmunity to erythroid differentiation (B-G) major histocompatibility complex alloantigens of the chicken

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

The control of humoral and associative antibody synthesis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Approaching the asymptote? Evolution and revolution in immunology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

The expression of influenza virus hemagglutinin in the pancreatic beta cells of transgenic mice results in autoimmune diabetes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

The costimulatory function of antigen-presenting cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

The regulatory functions of CD4+ and CD8+ T-cell subsets in immune class regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Peripheral selection of the T cell repertoire

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Induction of autoreactive B cells allows priming of autoreactive T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Immunological activity of covalently linked T-cell epitopes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Transgenic mice and analysis of B-cell tolerance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

A fail-safe mechanism for maintaining self-tolerance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

T cell tolerance by clonal elimination in the thymus

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Defective induction of antigen-reactive proliferating T cells in B cell-deprived mice. II. Anti-mu treatment affects the initiation and recruitment of T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15114

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Antigen-specific interaction between T and B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.1.185

Antigen-primed T cells from B cell-deficient JHD mice fail to provide B cell help

21 January 2018

1 reference

12 December 2020

CD4+8- help prevents rapid deletion of CD8+ cells after a transient response to antigen

1 reference

12 December 2020

Tolerance of erythrocytes in poultry:induction and specificity

1 reference

12 December 2020

Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft Rejection

1 reference

12 December 2020

Teetering on the brink of danger

1 reference

12 December 2020

Experimental autoimmune orchitis after neonatal thymectomy in the mouse

1 reference

12 December 2020

A cascade of T-T interactions, mediated by the linked recognition of antigen, in the induction of T cells able to help delayed-type hypersensitivity responses

1 reference

12 December 2020

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

1 reference

12 December 2020

On the control between cell-mediated, IgM and IgG immunity

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.96.1.185

1 reference

release_ky6mqwizhva75a3m2dhbaqndc4

4 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ky6mqwizhva75a3m2dhbaqndc4

24 November 2022

mapped directly with Wikidata item

PMCID

15114

1 reference

4 August 2017

1 reference

PubMed ID

9874793