The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases (Q34812506)

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English	The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases	scientific article

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8 December 2019

The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases (English)

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8 December 2019

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6

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8 December 2019

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L Huang

1

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8 December 2019

K K Ishii

2

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8 December 2019

H Zuccola

3

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8 December 2019

A M Gehring

4

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8 December 2019

C B Hwang

5

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8 December 2019

D M Coen

7

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8 December 2019

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1 January 1999

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8 December 2019

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6

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Proceedings of the National Academy of Sciences of the United States of America

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8 December 2019

96

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8 December 2019

2

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8 December 2019

447-452

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8 December 2019

Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.

1 reference

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

1 reference

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Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.

1 reference

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Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69

1 reference

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8 July 2018

Mutational studies of human DNA polymerase alpha. Identification of residues critical for deoxynucleotide binding and misinsertion fidelity of DNA synthesis.

1 reference

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8 July 2018

Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis.

1 reference

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Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

1 reference

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8 July 2018

Mutational studies of human DNA polymerase alpha. Lysine 950 in the third most conserved region of alpha-like DNA polymerases is involved in binding the deoxynucleoside triphosphate

1 reference

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8 July 2018

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

1 reference

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8 July 2018

Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.

1 reference

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8 July 2018

Generation of genetic diversity in herpes simplex virus: An antimutator phenotype maps to the DNA polymerase locus

1 reference

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8 July 2018

Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus

1 reference

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8 July 2018

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases

1 reference

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8 July 2018

Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene

1 reference

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8 July 2018

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

1 reference

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8 July 2018

Functional interaction between the herpes simplex-1 DNA polymerase and UL42 protein.

1 reference

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8 July 2018

The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity

1 reference

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Primary structure of the catalytic subunit of calf thymus DNA polymerase .delta.: sequence similarities with other DNA polymerases

1 reference

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8 July 2018

The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy

1 reference

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

1 reference

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Identification of small DNA fragments synthesized in herpes simplex virus-infected cells in the presence of acyclovir

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21 January 2018

Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase

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21 January 2018

Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants

1 reference

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21 January 2018

A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice

1 reference

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21 January 2018

Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U

1 reference

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21 January 2018

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

1 reference

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Modular organization of T4 DNA polymerase. Evidence from phylogenetics

1 reference

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Mutational analysis of the human DNA polymerase alpha. The most conserved region in alpha-like DNA polymerases is involved in metal-specific catalysis.

1 reference

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Novel interaction of aphidicolin with herpes simplex virus DNA polymerase and polymerase-associated exonuclease

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26 October 2018

Herpes simplex virus type 1 DNA polymerase. Mechanism of inhibition by acyclovir triphosphate

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Inhibition of viral polymerases by chain-terminating substrates: a kinetic analysis

1 reference

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Identifiers

10.1073/PNAS.96.2.447

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8 December 2019

1999PNAS...96..447H

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1 reference

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8 December 2019

1 reference

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8 December 2019

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