Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures (Q34823865)

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17 March 2020

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Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures (English)

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17 March 2020

Martin Puskarjov

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1

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Kristopher T Kahle

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Eva Ruusuvuori

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6 May 2014

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1 June 2014

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25 April 2019

28 November 2019

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55

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6

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Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1)

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An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo

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Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning

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8 July 2018

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8 July 2018

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Cation-chloride cotransporters and neuronal function

8 July 2018

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8 July 2018

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Inhibition and brain work

8 July 2018

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8 July 2018

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Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex.

8 July 2018

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NKCC1 transporter facilitates seizures in the developing brain

8 July 2018

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Energy metabolism in mammalian brain during development

8 July 2018

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The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum

8 July 2018

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Quantitative evolutionary design

8 July 2018

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Translating developmental time across mammalian species.

8 July 2018

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Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition

8 July 2018

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8 July 2018

Diuretic complications

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Sodium-potassium-chloride cotransport

8 July 2018

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Phenobarbital compared with phenytoin for the treatment of neonatal seizures.

8 July 2018

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The neuron-specific K-Cl cotransporter, KCC2. Antibody development and initial characterization of the protein

8 July 2018

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The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

8 July 2018

1 reference

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Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain

8 July 2018

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Blood-brain barrier permeation: molecular parameters governing passive diffusion

8 July 2018

1 reference

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Ontogeny of cation-Cl- cotransporter expression in rat neocortex

8 July 2018

1 reference

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Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain

8 July 2018

1 reference

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Partial cloning and characterization of Slc12a2: the gene encoding the secretory Na+-K+-2Cl- cotransporter

8 July 2018

1 reference

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Analysis of the variability in the pharmacokinetics and pharmacodynamics of bumetanide in critically ill infants.

8 July 2018

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Pharmacokinetics of bumetanide in critically ill infants

8 July 2018

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Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells

8 July 2018

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Clinical and EEG response to anticonvulsants in neonatal seizures

8 July 2018

1 reference

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Factors influencing the protein binding of bumetanide using an equilibrium dialysis technique

8 July 2018

1 reference

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Fate of [14C]-bumetanide in man

8 July 2018

1 reference

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Bumetanide and frusemide: a comparison of dose-response curves in healthy men.

8 July 2018

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Neonatal seizures and postneonatal epilepsy: a 7-y follow-up study.

8 July 2018

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Long-term prognosis in children with neonatal seizures: a population-based study.

21 January 2018

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Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study

21 January 2018

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Quantitation of Na+-K+-2Cl- cotransport splice variants in human tissues using kinetic polymerase chain reaction

21 January 2018

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Molecular and topological characterization of the rat parotid Na+-K+-2Cl- cotransporter1.

21 January 2018

1 reference

GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1.

21 January 2018

1 reference

Role of Cl- in cerebral vascular tone and expression of Na+-K+-2Cl- co-transporter after neonatal hypoxia-ischemia

21 January 2018

1 reference

Moderate-to-severe ischemic conditions increase activity and phosphorylation of the cerebral microvascular endothelial cell Na+-K+-Cl- cotransporter.

21 January 2018

1 reference

An autocrine neuronal interleukin-6 loop mediates chloride accumulation and NKCC1 phosphorylation in axotomized sensory neurons.

21 January 2018

1 reference

KCC2 interacts with the dendritic cytoskeleton to promote spine development

21 January 2018

1 reference

A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus

21 January 2018

1 reference

The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

21 January 2018

1 reference

Role of Cl- co-transporters in the excitation produced by GABAA receptors in juvenile bovine adrenal chromaffin cells.

21 January 2018

1 reference

Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke

21 January 2018

1 reference

Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs

21 January 2018

1 reference

Interactions of human organic anion transporters with diuretics.

21 January 2018

1 reference

Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide

21 January 2018

1 reference

Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy

21 January 2018

1 reference

Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsy

21 January 2018

1 reference

Pharmacokinetics and pharmacodynamics of intravenous bumetanide in mutant Nagase analbuminemic rats: importance of globulin binding for the pharmacodynamic effects

21 January 2018

1 reference

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

21 January 2018

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Bumetanide alleviates epileptogenic and neurotoxic effects of sevoflurane in neonatal rat brain.

21 January 2018

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Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats

21 January 2018

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Bumetanide for neonatal seizures: Based on evidence or enthusiasm?

21 January 2018

1 reference

Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility.

21 January 2018

1 reference

GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy.

21 January 2018

1 reference

Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.

21 January 2018

1 reference

Na(+)-dependent chloride transporter (NKCC1)-null mice exhibit less gray and white matter damage after focal cerebral ischemia

21 January 2018

1 reference

Inhibition of the Na+ -K+ -2Cl- -cotransporter in choroid plexus attenuates traumatic brain injury-induced brain edema and neuronal damage

21 January 2018

1 reference

Age- and dose-specific anticonvulsant action of bumetanide in immature rats.

21 January 2018

1 reference

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Interactions between heterotypic stressors and corticosterone reveal integrative mechanisms for controlling corticotropin-releasing hormone gene expression in the rat paraventricular nucleus.

26 October 2018

1 reference

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Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284054

Treatment of neonatal seizures

26 October 2018

1 reference

Protein binding and bilirubin displacing properties of bumetanide and furosemide

21 January 2018

1 reference

12 December 2020

Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics and the pharmacodynamics of bumetanide in rats

1 reference

12 December 2020

Computational prediction of oral drug absorption based on absorption rate constants in humans

1 reference

12 December 2020

A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential

1 reference

12 December 2020

Protein binding characteristics of bumetanide

1 reference

12 December 2020

Immunoreactive corticotropin-releasing hormone, adrenocorticotropin and cortisol in human plasma during pregnancy and delivery and postpartum

1 reference

12 December 2020

[Electroencephalography of the premature and term newborn. Maturational aspects and glossary]

1 reference

12 December 2020

Ionic composition of cisternal CSF in acute respiratory acidosis: lack of effect of large dose bumetanide

1 reference

12 December 2020

Identifiers

DOI

10.1111/EPI.12620

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24802699%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24802699%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

24802699

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24802699%20AND%20SRC:MED&resulttype=core&format=json