Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking (Q34830749)

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Language	Label	Description	Also known as
English	Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

4 August 2017

Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking (English)

1 reference

Europe PubMed Central

4 August 2017

author name string

R Aharoni

1

1 reference

Europe PubMed Central

4 August 2017

D Teitelbaum

2

1 reference

Europe PubMed Central

4 August 2017

R Arnon

3

1 reference

Europe PubMed Central

4 August 2017

M Sela

4

1 reference

Europe PubMed Central

4 August 2017

language of work or name

0 references

publication date

1 January 1999

1 reference

Europe PubMed Central

4 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

4 August 2017

96

1 reference

Europe PubMed Central

4 August 2017

2

1 reference

Europe PubMed Central

4 August 2017

634-639

1 reference

Europe PubMed Central

4 August 2017

Promiscuous binding of synthetic copolymer 1 to purified HLA-DR molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

TCR usage in human and experimental demyelinating disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

T suppressor hybridomas and interleukin-2-dependent lines induced by copolymer 1 or by spinal cord homogenate down-regulate experimental allergic encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Selective immunosuppression of class II-restricted T cells by MHC class II-binding peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Antigen analogs/MHC complexes as specific T cell receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Automated Synthesis of Peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

In vivo and in vitro immunological cross-reactions between basic encephalitogen and synthetic basic polypeptides capable of suppressing experimental allergic encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

T cell recognition as the target for immune intervention in autoimmune disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Cross-reactions and specificities of monoclonal antibodies against myelin basic protein and against the synthetic copolymer 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen–Ia complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Antigen Recognition and Peptide-Mediated Immunotherapy in Autoimmune Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Molecular Events Mediating T Cell Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. II. Biased T cell receptor V beta expression predominates in spinal cord infiltrating T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Synthetic copolymer 1 inhibits human T-cell lines specific for myelin basic protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

Molecular requirements involved in suppression of eae by synthetic basic copolymers of amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

8 July 2018

T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: structural requirements and clinical implications.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.2.634

21 January 2018

Effect of conformational propensity of peptide antigens in their interaction with MHC class II molecules. Failure to document the importance of regular secondary structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15188

26 October 2018

Basic encephalitogenic protein: A simplified purification on sulphoethyl-sephadex

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892685

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892685

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for IAs molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892685

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892685

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892685

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892685

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892685

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.96.2.634

1 reference

Europe PubMed Central

4 August 2017

1999PNAS...96..634A

0 references

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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