Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease (Q34832426)

4 August 2017

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title

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease (English)

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4 August 2017

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Gary P Anderson

1

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PubMed ID

18805339

4 August 2017

language of work or name

English

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publication date

1 September 2008

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4 August 2017

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4 August 2017

372

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4 August 2017

9643

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4 August 2017

1107-1119

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50 years of asthma: UK trends from 1955 to 2004

4 August 2017

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7 January 2021

Long-acting beta2-agonists versus theophylline for maintenance treatment of asthma

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7 January 2021

Long-acting beta2-agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma

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7 January 2021

Anti-IgE for chronic asthma in adults and children

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A systematic review and meta-analysis of interventions used to reduce exposure to house dust and their effect on the development and severity of asthma

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7 January 2021

TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives

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7 January 2021

Interleukin-4 is required for the induction of lung Th2 mucosal immunity

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7 January 2021

Changes in chromatin accessibility across the GM-CSF promoter upon T cell activation are dependent on nuclear factor kappaB proteins

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7 January 2021

The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections

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7 January 2021

In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma

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7 January 2021

External validity of randomised controlled trials in asthma: to whom do the results of the trials apply?

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7 January 2021

Severe asthma in adults: what are the important questions?

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7 January 2021

Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma.

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7 January 2021

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

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7 January 2021

Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an "endophenotype"

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7 January 2021

Lower airways inflammation in allergic rhinitics: a comparison with asthmatics and normal controls

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7 January 2021

Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa

1 reference

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7 January 2021

Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways.

1 reference

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7 January 2021

Allergen-induced bronchial inflammation in house dust mite-allergic patients with or without asthma.

1 reference

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7 January 2021

Comparison of allergen-induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients

1 reference

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7 January 2021

Airway inflammation in asthma and perennial allergic rhinitis. Relationship with nonspecific bronchial responsiveness and maximal airway narrowing

1 reference

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7 January 2021

What is the relationship between airway hyperresponsiveness and atopy?

1 reference

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7 January 2021

Mast-cell infiltration of airway smooth muscle in asthma.

1 reference

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7 January 2021

Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma

1 reference

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7 January 2021

Immunosuppressive therapy does not prevent the occurrence of immunoglobulin E-mediated allergies in children and adolescents with organ transplants.

1 reference

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7 January 2021

Interactions between corticosteroids and beta-adrenergic agonists in asthma disease induction, progression, and exacerbation

1 reference

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7 January 2021

Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids

1 reference

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7 January 2021

TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids

1 reference

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7 January 2021

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness

1 reference

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7 January 2021

Enhanced glucocorticoid receptor signaling in T cells impacts thymocyte apoptosis and adaptive immune responses

1 reference

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7 January 2021

FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma

1 reference

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7 January 2021

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

1 reference

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7 January 2021

Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

1 reference

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7 January 2021

Global strategy for asthma management and prevention: GINA executive summary.

1 reference

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7 January 2021

Clinical phenotypes of asthma

1 reference

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7 January 2021

Filaggrin variants confer susceptibility to asthma

1 reference

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7 January 2021

Glucocorticoids enhance or spare innate immunity: effects in airway epithelium are mediated by CCAAT/enhancer binding proteins

1 reference

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7 January 2021

Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study.

1 reference

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7 January 2021

Nonatopic Children with Multitrigger Wheezing Have Airway Pathology Comparable to Atopic Asthma

1 reference

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7 January 2021

Early intervention with inhaled corticosteroids in subjects with rapid decline in lung function and signs of bronchial hyperresponsiveness: Results from the DIMCA programme

1 reference

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7 January 2021

Wheezy babies--wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing

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7 January 2021

Gender differences in asthma development and progression

1 reference

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7 January 2021

Metabolomics applied to exhaled breath condensate in childhood asthma

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7 January 2021

Leukotrienes and 8-isoprostane in exhaled breath condensate of children with stable and unstable asthma

1 reference

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7 January 2021

IRAK-M is involved in the pathogenesis of early-onset persistent asthma

1 reference

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7 January 2021

An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway.

1 reference

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7 January 2021

Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma.

1 reference

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7 January 2021

Airway hyperresponsiveness is dissociated from airway wall structural remodeling.

1 reference

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7 January 2021

Inflammatory subtypes in asthma: assessment and identification using induced sputum

1 reference

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7 January 2021

Innate immune activation in neutrophilic asthma and bronchiectasis.

1 reference

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7 January 2021

Noneosinophilic asthma: a distinct clinical and pathologic phenotype

1 reference

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7 January 2021

Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines

1 reference

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7 January 2021

Factor analysis in the Genetics of Asthma International Network family study identifies five major quantitative asthma phenotypes

1 reference

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7 January 2021

An electronic nose in the discrimination of patients with asthma and controls

1 reference

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7 January 2021

The Melbourne Asthma Study: 1964-1999.

1 reference

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7 January 2021

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

1 reference

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7 January 2021

Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes

1 reference

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7 January 2021

Non-eosinophilic cor ticosteroid unresponsive asthma

1 reference

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7 January 2021

Variable p-CREB expression depicts different asthma phenotypes

1 reference

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7 January 2021

Association of the RIP2 gene with childhood atopic asthma

1 reference

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7 January 2021

Diminished lipoxin biosynthesis in severe asthma

1 reference

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7 January 2021

Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients

1 reference

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7 January 2021

New therapies for asthma

1 reference

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7 January 2021

Clinical consequences of ADRbeta2 polymorphisms

1 reference

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7 January 2021

Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast

1 reference

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7 January 2021

A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma

1 reference

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7 January 2021

Significant variability in response to inhaled corticosteroids for persistent asthma

1 reference

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7 January 2021

Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.

1 reference

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7 January 2021

Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma

1 reference

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7 January 2021

Human bronchial smooth muscle cells in culture produce stem cell factor

1 reference

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7 January 2021

Gene expression in asthmatic airway smooth muscle

1 reference

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7 January 2021

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

1 reference

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7 January 2021

How does airway inflammation modulate asthmatic airway constriction? An antigen challenge study.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Complex airway behavior and paradoxical responses to bronchoprovocation.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Airway constriction pattern is a central component of asthma severity: the role of deep inspirations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Self-organized patchiness in asthma as a prelude to catastrophic shifts.

1 reference

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7 January 2021

The structural basis of airways hyperresponsiveness in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Inhaled corticosteroids and the beneficial effect of deep inspiration in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Meta-analysis of genome-wide linkage studies of asthma and related traits

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

A longitudinal, population-based, cohort study of childhood asthma followed to adulthood

1 reference

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7 January 2021

Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years. A 30-year follow-up study.

1 reference

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7 January 2021

Risk factors associated with irreversible airflow limitation in asthma

1 reference

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7 January 2021

Scores of asthma and asthma severity reveal new regions of linkage in EGEA study families

1 reference

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7 January 2021

Determinants of lung function and airway hyperresponsiveness in asthmatic children.

1 reference

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7 January 2021

Risk factors from childhood to adulthood for bronchial responsiveness at age 32-42 yr

1 reference

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7 January 2021

Bronchial eosinophilic infiltration in Crohn's disease in the absence of pulmonary disease

1 reference

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7 January 2021

Increased levels of airway neutrophils reduce the inhibitory effects of inhaled glucocorticosteroids on allergen-induced airway eosinophils

1 reference

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7 January 2021

Epithelial Damage and Angiogenesis in the Airways of Children with Asthma

1 reference

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7 January 2021

Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma

1 reference

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7 January 2021

Lipid mediators as agonists for the resolution of acute lung inflammation and injury

1 reference

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7 January 2021

Risk factors of frequent exacerbations in difficult-to-treat asthma

1 reference

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7 January 2021

Rhinovirus infection in nonasthmatic subjects: effects on intrapulmonary airways

1 reference

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7 January 2021

Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection.

1 reference

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7 January 2021

Role of deficient type III interferon-λ production in asthma exacerbations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

1 reference

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7 January 2021

Wheeze and Asthma in Children

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Influence of body mass index on the response to asthma controller agents

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Maternal vitamin D intake during pregnancy and early childhood wheezing

1 reference

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7 January 2021

Vitamin D receptor-deficient mice fail to develop experimental allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation

1 reference

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7 January 2021

Prenatal stress enhances susceptibility of murine adult offspring toward airway inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Effects of environmental tobacco smoke exposure on pulmonary immune response in infant monkeys.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

The unpleasantness of perceived dyspnea is processed in the anterior insula and amygdala

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7 January 2021

Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Familial aggregation of severe, early-onset COPD : candidate gene approaches

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Smoking and airway hyperresponsiveness especially in the presence of blood eosinophilia increase the risk to develop respiratory symptoms: a 25-year follow-up study in the general adult population

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Determinants of response to fluticasone propionate and salmeterol/fluticasone propionate combination in the Gaining Optimal Asthma controL study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Smoking: a neglected cause of glucocorticoid resistance in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease

1 reference

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7 January 2021

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Comprehensive testing of positionally cloned asthma genes in two populations

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https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Functional relevance of the IL-23-IL-17 axis in lungs in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Neutrophils, interleukin-17A and lung disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes

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https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

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https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Stat3 and Stat4 direct development of IL-17-secreting Th cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function

1 reference

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7 January 2021

Regulation of inflammatory responses by IL-17F

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

A chitinase-like protein in the lung and circulation of patients with severe asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

The role of SHIP in macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

SHIP represses the generation of alternatively activated macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

Genetics of asthma and COPD. Similar results for different phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961452-X

7 January 2021

10.1016/S0140-6736(08)61452-X

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

18805339