RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction (Q34836681)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184671%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction (English)

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29 December 2019

0 references

1 reference

4

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9

Wayne J G Hellstrom

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29 December 2019

10

Philip J Kadowitz

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29 December 2019

author name string

Trinity J Bivalacqua

1

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29 December 2019

Hunter C Champion

2

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29 December 2019

Mustafa F Usta

3

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29 December 2019

Kanchan Chitaley

5

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29 December 2019

R Clinton Webb

6

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Ronald L Lewis

7

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29 December 2019

Thomas M Mills

8

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29 December 2019

language of work or name

English

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publication date

7 June 2004

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Proceedings of the National Academy of Sciences of the United States of America

29 December 2019

published in

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29 December 2019

volume

101

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issue

24

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page(s)

9121-9126

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Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease

29 December 2019

cites work

1 reference

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Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase

8 July 2018

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Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function

8 July 2018

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Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats

8 July 2018

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Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

8 July 2018

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RhoA-mediated Ca2+ sensitization in erectile function

8 July 2018

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Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection

8 July 2018

1 reference

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Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases

8 July 2018

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Epidemiology of erectile dysfunction

8 July 2018

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Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum

8 July 2018

1 reference

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cGMP-dependent protein kinase phosphorylates and inactivates RhoA.

8 July 2018

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Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway.

8 July 2018

1 reference

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Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

8 July 2018

1 reference

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Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

8 July 2018

1 reference

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Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat.

8 July 2018

1 reference

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A role for Rho in Ras transformation

8 July 2018

1 reference

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Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence

8 July 2018

1 reference

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Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission

8 July 2018

1 reference

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Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation

8 July 2018

1 reference

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Diabetes impairs endothelium-dependent relaxation of human penile vascular tissues mediated by NO and EDHF.

8 July 2018

1 reference

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Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta

21 January 2018

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Two phases of nitrergic neuropathy in streptozotocin-induced diabetic rats

21 January 2018

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Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat.

21 January 2018

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Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction

21 January 2018

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Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats

21 January 2018

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Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: a possible cause for erectile dysfunction in diabetes.

21 January 2018

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Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.

21 January 2018

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Regulation by GDI of RhoA/Rho-kinase-induced Ca2+ sensitization of smooth muscle myosin II.

21 January 2018

1 reference

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Human and rabbit cavernosal smooth muscle cells express Rho-kinase

26 October 2018

1 reference

12 December 2020

Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats

1 reference

12 December 2020

Nitric oxide: a physiologic mediator of penile erection

1 reference

12 December 2020

3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0400520101

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29 December 2019

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29 December 2019

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