Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer (Q34849073)

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English	Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer	scientific article

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scholarly article

1 reference

Europe PubMed Central

4 August 2017

Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer (English)

1 reference

Europe PubMed Central

4 August 2017

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Akaash K Mishra

1

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Europe PubMed Central

4 August 2017

Silvana S Dormi

2

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Europe PubMed Central

4 August 2017

Alaina M Turchi

3

1 reference

Europe PubMed Central

4 August 2017

Derek S Woods

4

1 reference

Europe PubMed Central

4 August 2017

John J Turchi

5

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Europe PubMed Central

4 August 2017

language of work or name

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publication date

4 November 2014

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Europe PubMed Central

4 August 2017

Biochemical Pharmacology

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Europe PubMed Central

4 August 2017

93

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Europe PubMed Central

4 August 2017

1

1 reference

Europe PubMed Central

4 August 2017

25-33

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Europe PubMed Central

4 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4285624/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Structure and conformational change of a replication protein A heterotrimer bound to ssDNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Detection of posttranslational modifications of replication protein A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis

1 reference

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8 July 2018

Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Targeting the OB-Folds of Replication Protein A with Small Molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

DNA polymerase eta and chemotherapeutic agents

1 reference

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8 July 2018

Interrogation of nucleotide excision repair capacity: impact on platinum-based cancer therapy

1 reference

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8 July 2018

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

1 reference

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8 July 2018

Functional characterization of a cancer causing mutation in human replication protein A

1 reference

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8 July 2018

Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Drug combination studies and their synergy quantification using the Chou-Talalay method

1 reference

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8 July 2018

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Platinum resistance: the role of DNA repair pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Homologous recombination in DNA repair and DNA damage tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Replication protein A is an independent prognostic indicator with potential therapeutic implications in colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

A dynamic model for replication protein A (RPA) function in DNA processing pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Use of autoantibodies in breast cancer screening and diagnosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Formation and repair of interstrand cross-links in DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Autoimmunity to the M(r) 32,000 subunit of replication protein A in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Functional analysis of the four DNA binding domains of replication protein A. The role of RPA2 in ssDNA binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Replication protein A (RPA) binding to duplex cisplatin-damaged DNA is mediated through the generation of single-stranded DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Etoposide: four decades of development of a topoisomerase II inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Induction of apoptosis in cisplatin-sensitive and -resistant human ovarian cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Role of platinum-DNA adduct formation and removal in cisplatin resistance in human ovarian cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Experimental model systems of ovarian cancer: applications to the design and evaluation of new treatment approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285624

8 July 2018

First-line chemotherapy for non-small-cell lung cancer: is there a superior regimen based on histology?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25449597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Focus on epithelial ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25449597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of minor adducts in cisplatin-modified DNA by transcription footprinting

1 reference

https://pubmed.ncbi.nlm.nih.gov/25449597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BCP.2014.10.013

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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