The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence. (Q34856009)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25011011%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence (English)

1 reference

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9 March 2020

main subject

Cryptococcus neoformans

1 reference

2

1 reference

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9 March 2020

author name string

Fabiano Assis de Gontijo

1

1 reference

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9 March 2020

Larissa Fernandes

3

1 reference

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9 March 2020

Joel Machado

4

1 reference

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9 March 2020

J Andrew Alspaugh

5

1 reference

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9 March 2020

Marcelo A Vallim

6

1 reference

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9 March 2020

publication date

7 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25011011%20AND%20SRC:MED&resulttype=core&format=json

Fungal Genetics and Biology

9 March 2020

published in

1 reference

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9 March 2020

volume

70

1 reference

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9 March 2020

page(s)

12-23

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Inhibition of nucleotide biosynthesis potentiates the antifungal activity of amphotericin B.

9 March 2020

cites work

1 reference

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The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host

8 July 2018

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Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

8 July 2018

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Genetic circuits that govern bisexual and unisexual reproduction in Cryptococcus neoformans

8 July 2018

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Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans

8 July 2018

1 reference

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Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms

8 July 2018

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8 July 2018

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Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress

8 July 2018

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De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

8 July 2018

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Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway

8 July 2018

1 reference

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Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae

8 July 2018

1 reference

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Structure of dihydroorotase fromBacillus anthracisat 2.6 Å resolution

8 July 2018

1 reference

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Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii

8 July 2018

1 reference

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Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway.

8 July 2018

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8 July 2018

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Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation

8 July 2018

1 reference

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Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants

8 July 2018

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Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.

8 July 2018

1 reference

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Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

8 July 2018

1 reference

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Signalling pathways in the pathogenesis of Cryptococcus

8 July 2018

1 reference

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Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

Threonine biosynthetic genes are essential in Cryptococcus neoformans.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

Cryptococcus neoformans, a fungus under stress

8 July 2018

1 reference

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Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo

8 July 2018

1 reference

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Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi

8 July 2018

1 reference

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Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis

8 July 2018

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Light controls growth and development via a conserved pathway in the fungal kingdom

8 July 2018

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Fungal virulence, vertebrate endothermy, and dinosaur extinction: is there a connection?

8 July 2018

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Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus

8 July 2018

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Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans

8 July 2018

1 reference

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Cryptococcus neoformans virulence gene discovery through insertional mutagenesis

8 July 2018

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Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages

8 July 2018

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E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases

8 July 2018

1 reference

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

8 July 2018

1 reference

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A PCR-based strategy to generate integrative targeting alleles with large regions of homology.

8 July 2018

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

8 July 2018

1 reference

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Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment

8 July 2018

1 reference

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Infections of the central nervous system in transplant recipients

8 July 2018

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Ustilago maydis--a valuable model system for the study of fungal dimorphism and virulence

8 July 2018

1 reference

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Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans

8 July 2018

1 reference

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RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans

8 July 2018

1 reference

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Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

8 July 2018

1 reference

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Urease as a virulence factor in experimental cryptococcosis

8 July 2018

1 reference

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Potential role of phospholipases in virulence and fungal pathogenesis

8 July 2018

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Characterization of the glyceraldehyde-3-phosphate dehydrogenase gene [correction of glyceraldehyde-3-phosphate gene] and the use of its promoter for heterologous expression in Cryptococcus neoformans, a human pathogen

8 July 2018

1 reference

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Isolation of the third capsule-associated gene, CAP60, required for virulence in Cryptococcus neoformans

8 July 2018

1 reference

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Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials Group

8 July 2018

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Genetics of Ustilago maydis, a fungal pathogen that induces tumors in maize

8 July 2018

1 reference

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A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum

8 July 2018

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The second capsule gene of cryptococcus neoformans, CAP64, is essential for virulence.

8 July 2018

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Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.

8 July 2018

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Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA

8 July 2018

1 reference

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The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid.

8 July 2018

1 reference

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Isogenic strain construction and gene mapping in Candida albicans.

8 July 2018

1 reference

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Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence

8 July 2018

1 reference

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Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants.

8 July 2018

1 reference

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Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide

8 July 2018

1 reference

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Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice

8 July 2018

1 reference

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Toxicity of the pyrimidine biosynthetic pathway intermediate carbamyl aspartate in Salmonella typhimurium

8 July 2018

1 reference

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How do the polyene macrolide antibiotics affect the cellular membrane properties?

8 July 2018

1 reference

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Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans

8 July 2018

1 reference

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Overview of medically important antifungal azole derivatives

8 July 2018

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Structure of the Saccharomyces cerevisiae URA4 gene encoding dihydroorotase

8 July 2018

1 reference

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cis- and trans-acting regulatory elements of the yeast URA3 promoter

8 July 2018

1 reference

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Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation

8 July 2018

1 reference

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Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium

8 July 2018

1 reference

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Selection of ura5 and ura3 mutants from the two varieties of Cryptococcus neoformans on 5-fluoroorotic acid medium

8 July 2018

1 reference

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Molecular and genetic analysis of URA5 transformants of Cryptococcus neoformans

8 July 2018

1 reference

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The influence of congo red on the cell wall and (1----3)-beta-D-glucan microfibril biogenesis in Saccharomyces cerevisiae

8 July 2018

1 reference

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Identification of dihydroorotate dehydrogenase as a relevant drug target for 1-hydroxyquinolones in Toxoplasma gondii

8 July 2018

1 reference

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Identification of fungal cell wall mutants using susceptibility assays based on Calcofluor white and Congo red.

26 October 2018

1 reference

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High frequency transformation of Cryptococcus neoformans and Cryptococcus gattii by Agrobacterium tumefaciens

26 October 2018

1 reference

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Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence

26 October 2018

1 reference

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Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

Unexpected diversity in the fine specificity of monoclonal antibodies that use the same V region gene to glucuronoxylomannan of Cryptococcus neoformans

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

Calcineurin is required for virulence of Cryptococcus neoformans

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286198

Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

26 October 2018

1 reference

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Novel gene functions required for melanization of the human pathogenCryptococcus neoformans

26 October 2018

1 reference

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Need for Alternative Trial Designs and Evaluation Strategies for Therapeutic Studies of Invasive Mycoses

9 December 2018

1 reference

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Plate method for detection of phospholipase activity in Candida albicans

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25011011

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The capsule of cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25011011

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.FGB.2014.06.003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25011011%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25011011%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

25011011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25011011%20AND%20SRC:MED&resulttype=core&format=json