Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders (Q34861234)

4 August 2017

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title

Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders (English)

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4 August 2017

3

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4 August 2017

Stephen J Glatt

1

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author name string

Ori S Cohen

series ordinal

2

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PubMed ID

21438146

4 August 2017

Ming T Tsuang

series ordinal

4

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4 August 2017

22 March 2011

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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

4 August 2017

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4 August 2017

156B

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4 August 2017

4

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4 August 2017

382-392

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Alternatively Spliced Genes as Biomarkers for Schizophrenia, Bipolar Disorder and Psychosis: A Blood-Based Spliceome-Profiling Exploratory Study

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Deciphering the splicing code

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Molecular diversity through RNA editing: a balancing act.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Aberrant RNA processing events in neurological disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Understanding mechanisms underlying human gene expression variation with RNA sequencing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Analysis of whole genome biomarker expression in blood and brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

RNA-seq: from technology to biology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Genotypic analysis of gene expression in the dissection of the aetiology of complex neurological and psychiatric diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Decrypting the genome's alternative messages

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Expression of RGS4 splice variants in dorsolateral prefrontal cortex of schizophrenic and bipolar disorder patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Regulation of a novel alphaN-catenin splice variant in schizophrenic smokers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Neuronal regulation of alternative pre-mRNA splicing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Discovery of tissue-specific exons using comprehensive human exon microarrays

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Genome wide gene expression studies in mood disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Got diversity? Wiring the fly brain with Dscam

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Defective splicing, disease and therapy: searching for master checkpoints in exon definition.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Gene expression profiling in schizophrenia and related mental disorders.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

The involvement of ErbB4 with schizophrenia: association and expression studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

An old story with a new twist: do NMDAR1 mRNA binding proteins regulate expression of the NMDAR1 receptor in the presence of alcohol?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Variation in alternative splicing across human tissues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

A novel PTB-PDZ domain interaction mediates isoform-specific ubiquitylation of mammalian Numb

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Postmortem brain abnormalities of the glutamate neurotransmitter system in autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Alternative RNA splicing in the nervous system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Proteomics: new perspectives, new biomedical opportunities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Distinct functions of the two isoforms of dopamine D2 receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Altered ratios of alternatively spliced long and short gamma2 subunit mRNAs of the gamma-amino butyrate type A receptor in prefrontal cortex of schizophrenics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Molecular cloning and characterization of human FGF8 alternative messenger RNA forms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Structure and sequence of human FGF8

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082621

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

8 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Cell-specific alternative splicing increases calcium channel current density in the pain pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Altered serotonin 2C receptor RNA splicing in suicide: association with editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Alternative splicing in disease and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

NGF enhances depolarization effects on SNAP-25 expression: induction of SNAP-25b isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Alternative splicing matters: N-type calcium channels in nociceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Tissue distribution of Ca2+-dependent activator protein for secretion family members CAPS1 and CAPS2 in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Evaluating the comparability of gene expression in blood and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Ca2+ and pH modulate alternative splicing of exon 5 in NMDA receptor subunit 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

VASE-containing N-CAM isoforms are increased in the hippocampus in bipolar disorder but not schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FAJMG.B.31181

Distributions of exons and introns in the human genome

21 January 2018

1 reference

12 December 2020

FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development

1 reference

12 December 2020

Effects of chronic alcohol consumption on the expression of different NR1 splice variants in the brain of AA and ANA lines of rats

1 reference

12 December 2020

Change in plasma membrane Ca2(+)-ATPase splice-variant expression in response to a rise in intracellular Ca2+

1 reference

12 December 2020

Increased levels of expression of an NMDAR1 splice variant in the superior temporal gyrus in schizophrenia

1 reference

12 December 2020

Identifiers

DOI

10.1002/AJMG.B.31181

1 reference

4 August 2017

1 reference

4 August 2017

1 reference

PubMed ID

21438146