An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA. (Q34864952)

5 August 2017

title

An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA. (English)

1 reference

5 August 2017

Fan Zhang

1

1 reference

5 August 2017

Alan G Hinnebusch

series ordinal

2

1 reference

5 August 2017

language of work or name

English

0 references

publication date

11 January 2011

1 reference

5 August 2017

published in

Nucleic Acids Research

1 reference

5 August 2017

volume

39

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5 August 2017

issue

8

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5 August 2017

page(s)

3128-3140

1 reference

Creative Commons Attribution-NonCommercial 2.5 Generic

5 August 2017

copyright license

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Kinetic and thermodynamic analysis of the role of start codon/anticodon base pairing during eukaryotic translation initiation

8 July 2018

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Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4.

8 July 2018

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eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA.

8 July 2018

1 reference

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Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

8 July 2018

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Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo

8 July 2018

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Global translational responses to oxidative stress impact upon multiple levels of protein synthesis.

8 July 2018

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Translational regulation of GCN4 and the general amino acid control of yeast

8 July 2018

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Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

8 July 2018

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Dissecting eukaryotic translation and its control by ribosome density mapping

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation

8 July 2018

1 reference

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

8 July 2018

1 reference

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YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed

8 July 2018

1 reference

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Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

8 July 2018

1 reference

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Physical evidence for distinct mechanisms of translational control by upstream open reading frames

8 July 2018

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Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast

8 July 2018

1 reference

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TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitation

8 July 2018

1 reference

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

8 July 2018

1 reference

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Regulated degradation of the transcription factor Gcn4.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Positive regulation in the general amino acid control of Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Multiple upstream AUG codons mediate translational control of GCN4.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

The first and fourth upstream open reading frames in GCN4 mRNA have similar initiation efficiencies but respond differently in translational control to change in length and sequence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Genetic selection for mutations that reduce or abolish ribosomal recognition of the HIS4 translational initiator region

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

The scanning model for translation: an update

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082883

Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21227927

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Translational efficiency of a non-AUG initiation codon is significantly affected by its sequence context in yeast

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21227927

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Monitoring the Gcn4 protein-mediated response in the yeast Saccharomyces cerevisiae

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21227927

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKQ1251

1 reference

5 August 2017

1 reference

5 August 2017

1 reference