Nuclear receptor subfamily 0 group B member 2 (Q3486853)

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mammalian protein found in Homo sapiens

nuclear receptor SHP
NR0B2
nuclear receptor subfamily 0 group B member 2
orphan nuclear receptor SHP
small heterodimer partner

Language	Label	Description	Also known as
English	Nuclear receptor subfamily 0 group B member 2	mammalian protein found in Homo sapiens	nuclear receptor SHP NR0B2 nuclear receptor subfamily 0 group B member 2 orphan nuclear receptor SHP small heterodimer partner

Statements

1 reference

13 November 2019

UniProt protein ID

Nuclear hormone receptor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15466

nuclear receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15466

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

protein homodimerization activity

determination method

1 reference

9 May 2019

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

protein domain specific binding

determination method

1 reference

9 May 2019

LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

steroid hormone receptor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

protein binding

determination method

7 references

9 May 2019

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

transcription corepressor activity

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

1 reference

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

protein-containing complex binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

transcription factor binding

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15466&geneProductId=UniProtKB:Q15466

determination method

retinoic acid receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

peroxisome proliferator activated receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

retinoid X receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

thyroid hormone receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

transcription corepressor activity

determination method

3 references

9 May 2019

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

determination method

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15466&geneProductId=UniProtKB:Q15466

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15466&geneProductId=UniProtKB:Q15466

determination method

24 April 2018

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15466&geneProductId=UniProtKB:Q15466

determination method

24 April 2018

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15466&geneProductId=UniProtKB:Q15466

determination method

protein-containing complex

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

biological process

Notch signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

cholesterol metabolic process

determination method

1 reference

9 May 2019

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

response to glucose

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

24 April 2018

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15466&geneProductId=UniProtKB:Q15466

determination method

negative regulation of gene expression

determination method

1 reference

9 May 2019

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15466&geneProductId=UniProtKB:Q15466

determination method

positive regulation of gene expression

determination method

1 reference

9 May 2019

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

animal organ regeneration

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

transcription initiation from RNA polymerase II promoter

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15466&geneProductId=UniProtKB:Q15466

determination method

positive regulation of insulin secretion

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

steroid hormone mediated signaling pathway

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

negative regulation of transcription by RNA polymerase II

determination method

3 references

9 May 2019

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

negative regulation of DNA-binding transcription factor activity

determination method

circadian rhythm

determination method

1 reference

9 May 2019

Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

rhythmic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15466

determination method

Gene Atlas image

PBB GE NR0B2 206410 at fs.png
732 × 530; 11 KB

0 references

Nuclear hormone receptor, ligand-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15466

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000254227

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000254227

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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