Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure (Q34892110)

5 August 2017

1 reference

title

Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure (English)

1 reference

5 August 2017

0 references

Michikado Iwata

1

1 reference

5 August 2017

Randy T Cowling

series ordinal

2

1 reference

5 August 2017

Seon Ju Yeo

series ordinal

3

1 reference

5 August 2017

Barry Greenberg

series ordinal

4

1 reference

5 August 2017

publication date

13 December 2010

1 reference

Journal of Molecular and Cellular Cardiology

5 August 2017

published in

1 reference

5 August 2017

volume

51

1 reference

5 August 2017

issue

4

1 reference

5 August 2017

page(s)

542-547

1 reference

Effects of ACE2 Inhibition in the Post-Myocardial Infarction Heart

5 August 2017

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Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial

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8 July 2018

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Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas

8 July 2018

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Angiotensin-converting enzyme 2 is an essential regulator of heart function

8 July 2018

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Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

8 July 2018

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A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

8 July 2018

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A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

8 July 2018

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8 July 2018

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Mas oncogene signaling and transformation require the small GTP-binding protein Rac

8 July 2018

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Local angiotensin II generation in the rat heart: role of renin uptake.

8 July 2018

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Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes

8 July 2018

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Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes

8 July 2018

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Structural basis of end-stage failure in ischemic cardiomyopathy in humans

8 July 2018

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Identification of functional angiotensin II receptors on rat cardiac fibroblasts

8 July 2018

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Expression of the MAS proto-oncogene in the retinal pigment epithelium of the rhesus macaque

8 July 2018

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Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues

8 July 2018

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Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications

8 July 2018

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Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure

8 July 2018

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The mas proto-oncogene is developmentally regulated in the rat central nervous system

8 July 2018

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Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators

8 July 2018

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8 July 2018

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Angiotensin-(1-7) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas.

26 October 2018

1 reference

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Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme

26 October 2018

1 reference

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Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085048

Angiotensin-(1-7) through AT receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway

26 October 2018

1 reference

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Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells.

26 October 2018

1 reference

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Angiotensin metabolites can stimulate receptors of the Mas-related genes family

26 October 2018

1 reference

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The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats

26 October 2018

1 reference

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Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.

26 October 2018

1 reference

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Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology

26 October 2018

1 reference

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Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts.

26 October 2018

1 reference

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Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function

26 October 2018

1 reference

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Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways.

26 October 2018

1 reference

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Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat

26 October 2018

2 references

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26 October 2018

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ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR.

9 December 2018

1 reference

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Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II.

26 October 2018

1 reference

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26 October 2018

1 reference

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Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients

26 October 2018

1 reference

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Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats.

26 October 2018

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Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects

26 October 2018

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26 October 2018

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Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.

26 October 2018

1 reference

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Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure

26 October 2018

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G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

26 October 2018

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IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart

26 October 2018

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26 October 2018

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Angiotensin-(1-7) attenuates neointimal formation after stent implantation in the rat.

26 October 2018

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Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors

26 October 2018

1 reference

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Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2.

26 October 2018

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Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors

26 October 2018

1 reference

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Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts

26 October 2018

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Vascular Relaxation, Antihypertensive Effect, and Cardioprotection of a Novel Peptide Agonist of the Mas Receptor

26 October 2018

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9 December 2018

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9 December 2018

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Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization

7 January 2021

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Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor

7 January 2021

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Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats

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7 January 2021

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Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction

7 January 2021

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Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction. Results of the SOLVD echocardiography substudy

7 January 2021

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The angiotensin receptor type 1-Gq protein-phosphatidyl inositol phospholipase Cbeta-protein kinase C pathway is involved in activation of proximal tubule Na+-ATPase activity by angiotensin(1-7) in pig kidneys

7 January 2021

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Angiotensin-(1–7) Attenuates the Development of Heart Failure After Myocardial Infarction in Rats

7 January 2021

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Angiotensin-(1-7) prevents diabetes-induced cardiovascular dysfunction

7 January 2021

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Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991

7 January 2021

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The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction

7 January 2021

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Renin-angiotensin system and myocardial collagen matrix: modulation of cardiac fibroblast function by angiotensin II type 1 receptor antagonism

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21147120

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

AVE 0991-angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoE-knockout mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21147120

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.YJMCC.2010.12.003

1 reference

5 August 2017

1 reference

5 August 2017

1 reference