Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis. (Q34896844)

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English	Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis.	scientific article

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17 January 2020

Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis (English)

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17 January 2020

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17 January 2020

Bruce N Cronstein

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17 January 2020

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Avani Desai

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6 March 2006

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17 January 2020

Arthritis Research and Therapy

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17 January 2020

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17 January 2020

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17 January 2020

R53

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17 January 2020

https://scigraph.springernature.com/pub.10.1186/ar1914

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Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis

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8 July 2018

Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery

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An historical overview of the treatment of Crohn's disease: why do we need biological therapies?

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8 July 2018

The use of methotrexate in rheumatoid arthritis

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8 July 2018

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Azathioprine and methotrexate in multiple sclerosis

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8 July 2018

Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis.

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8 July 2018

Methotrexate and psoriasis in the era of new biologic agents

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8 July 2018

Adenosine: an endogenous regulator of innate immunity

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Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells.

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8 July 2018

Signalling from adenosine receptors to mitogen-activated protein kinases

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Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin

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Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.

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8 July 2018

Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells.

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8 July 2018

Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells

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8 July 2018

A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice

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8 July 2018

Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10.

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8 July 2018

Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists

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8 July 2018

Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation

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8 July 2018

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides

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8 July 2018

Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors

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8 July 2018

Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation. The role of N-methyl-D-aspartate receptors

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8 July 2018

Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice.

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8 July 2018

Folate supplementation and methotrexate

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Inhibition of human monocyte TNF production by adenosine receptor agonists

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8 July 2018

Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function

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8 July 2018

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

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8 July 2018

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

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8 July 2018

Engagement of adenosine receptors inhibits hydrogen peroxide (H2O2-) release by activated human neutrophils

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8 July 2018

Kinetics of changes in peritoneal cell populations following acute inflammation

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8 July 2018

Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory

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8 July 2018

The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats

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8 July 2018

The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively

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8 July 2018

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells

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8 July 2018

Antiinflammatory effect of A3 adenosine receptor agonists in murine autoimmune arthritis models.

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26 October 2018

Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.

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26 October 2018

The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

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26 October 2018

Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis

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26 October 2018

Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.

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26 October 2018

Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulation

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26 October 2018

Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms

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Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression

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26 October 2018

Adenosine enhances IL-10 secretion by human monocytes

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12 December 2020

based on heuristic

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Adenosine plasma levels after low dose methotrexate administration

1 reference

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12 December 2020

based on heuristic

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Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation

1 reference

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12 December 2020

based on heuristic

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IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat ad

1 reference

https://pubmed.ncbi.nlm.nih.gov/16519795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate in Crohn's disease: long-term efficacy and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16519795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced in vitro induced production of interleukin 10 by peripheral blood mononuclear cells in rheumatoid arthritis is associated with clinical response to methotrexate treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16519795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of (R)-N-(1-methyl-2-phenylethyl) adenosine (L-PIA), a standard A1-selective adenosine agonist on rat acute models of inflammation and neutrophil function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16519795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulatory effects of adenosine on cytokine release by activated human monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16519795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating interleukin 10 and interleukin-6 serum levels in rheumatoid arthritis patients treated with methotrexate or gold salts: preliminary report

1 reference

https://pubmed.ncbi.nlm.nih.gov/16519795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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17 January 2020

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17 January 2020

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