Tumor physiology and charge dynamics of anticancer drugs: implications for camptothecin-based drug development (Q34915928)

5 August 2017

title

Tumor physiology and charge dynamics of anticancer drugs: implications for camptothecin-based drug development (English)

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5 August 2017

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D J Adams

1

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5 August 2017

L R Morgan

series ordinal

2

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5 August 2017

language of work or name

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1 January 2011

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Current Medicinal Chemistry

5 August 2017

published in

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5 August 2017

volume

18

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5 August 2017

issue

9

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5 August 2017

page(s)

1367-1372

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BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors

5 August 2017

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titr

8 July 2018

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Cancer's molecular sweet tooth and the Warburg effect.

8 July 2018

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Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient

8 July 2018

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8 July 2018

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8 July 2018

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The impact of tumor physiology on camptothecin-based drug development

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

8 July 2018

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The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells

8 July 2018

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Kinetics of lactone hydrolysis in antitumor drugs of camptothecin series as studied by fluorescence spectroscopy.

8 July 2018

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Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer

8 July 2018

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DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues

8 July 2018

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Evaluation of pKa estimation methods on 211 druglike compounds.

8 July 2018

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A novel approach for organelle-specific DNA damage targeting reveals different susceptibility of mitochondrial DNA to the anticancer drugs camptothecin and topotecan

26 October 2018

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Benchmarking and validating algorithms that estimate pK(a) values of drugs based on their molecular structures.

26 October 2018

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Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents

26 October 2018

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The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models

26 October 2018

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Understanding the tumor metabolic phenotype in the genomic era.

26 October 2018

1 reference

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pH and drug resistance in tumors.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086837

Camptothecin analogues with enhanced antitumor activity at acidic pH.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086837

Critical Compilation of pK(a) Values for Pharmaceutical Substances

26 October 2018

1 reference

12 December 2020

Comparison of nine programs predicting pK(a) values of pharmaceutical substances

1 reference

12 December 2020

The Important Role of Albumin in Determining the Relative Human Blood Stabilities of the Camptothecin Anticancer Drugs

1 reference

12 December 2020

Preferential binding of the carboxylate form of camptothecin by human serum albumin

1 reference

12 December 2020

Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics

1 reference

12 December 2020

10.2174/092986711795029609

Identifiers

DOI

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5 August 2017

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5 August 2017

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