Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism. (Q34922937)

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English	Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism.	scientific article

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14 January 2020

Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism (English)

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14 January 2020

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Ayman Elsheikh

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14 January 2020

Sidonie N Lavergne

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14 January 2020

Haiyi Wang

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Jean Sathish

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14 January 2020

Werner J Pichler

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14 January 2020

B Kevin Park

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14 January 2020

Dean J Naisbitt

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27 October 2010

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14 January 2020

Journal of Immunology

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185

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14 January 2020

6448-6460

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14 January 2020

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo.

1 reference

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8 July 2018

Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction

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8 July 2018

"Danger" conditions increase sulfamethoxazole-protein adduct formation in human antigen-presenting cells

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8 July 2018

Antigen processing and MHC-II presentation by dermal and tumor-infiltrating dendritic cells

1 reference

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8 July 2018

2. Dendritic cells as regulators of immunity and tolerance

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8 July 2018

High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity

1 reference

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8 July 2018

Immune responses to abacavir in antigen-presenting cells from hypersensitive patients.

1 reference

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8 July 2018

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

1 reference

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8 July 2018

Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells

1 reference

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8 July 2018

Activation of T cells by carbamazepine and carbamazepine metabolites

1 reference

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8 July 2018

Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts

1 reference

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Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model

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8 July 2018

Characterization of the formation and localization of sulfamethoxazole and dapsone-associated drug-protein adducts in human epidermal keratinocytes

1 reference

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8 July 2018

Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells.

1 reference

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8 July 2018

Molecular identification of a danger signal that alerts the immune system to dying cells

1 reference

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8 July 2018

T-cell involvement in drug-induced acute generalized exanthematous pustulosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

Myeloperoxidase is involved in H2O2-induced apoptosis of HL-60 human leukemia cells

1 reference

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8 July 2018

Natural adjuvants: endogenous activators of dendritic cells

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8 July 2018

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

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8 July 2018

High IL-5 production by human drug-specific T cell clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

8 July 2018

Stimulation of human T cells with sulfonamides and sulfonamide metabolites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives.

1 reference

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26 October 2018

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS.

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26 October 2018

Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso

1 reference

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26 October 2018

Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions

1 reference

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26 October 2018

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.

1 reference

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26 October 2018

Oxidative stress mediated idiosyncratic drug toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

CpG immunostimulatory sequences enhance contact hypersensitivity responses in mice.

1 reference

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26 October 2018

NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Coupling of contact sensitizers to thiol groups is a key event for the activation of monocytes and monocyte-derived dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Haptenation of sulfonamide reactive metabolites to cellular proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

T cell recognition of penicillin G: structural features determining antigenic specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

An innate sense of danger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

26 October 2018

Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

9 December 2018

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087426

9 December 2018

Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple cytochrome P450-isoenzymes mRNA are expressed in dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADH-dependent reduction of sulphamethoxazole hydroxylamine in dog and human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predisposition to phenytoin hepatotoxicity assessed in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishing lymphoblastoid cell lines from frozen blood of extremely old individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential involvement of dendritic cells in delayed-type hypersensitivity reactions to β-lactams

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1000889

1 reference

Europe PubMed Central

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14 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20980635%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20980635%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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