Gene silencing in mammals by small interfering RNAs (Q34931992)

5 August 2017

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title

Gene silencing in mammals by small interfering RNAs (English)

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5 August 2017

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5 August 2017

Phillip A Sharp

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5 August 2017

1 October 2002

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5 August 2017

Nature Reviews Genetics

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5 August 2017

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737-747

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10

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https://scigraph.springernature.com/pub.10.1038/nrg908

5 August 2017

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cites work

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31 March 2020

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A species of small antisense RNA in posttranscriptional gene silencing in plants

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference.

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Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos.

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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RNA interference is mediated by 21- and 22-nucleotide RNAs

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RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase

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RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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ATP requirements and small interfering RNA structure in the RNA interference pathway

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Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells

31 March 2020

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

31 March 2020

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

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The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA

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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

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Control of developmental timing in animals

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Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

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RNA interference--2001.

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Non-coding RNA's: lightning strikes twice

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

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Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

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Double-stranded RNA as a template for gene silencing

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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

31 March 2020

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A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

31 March 2020

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ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos

31 March 2020

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Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance

31 March 2020

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Argonaute2, a link between genetic and biochemical analyses of RNAi

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Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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Identification of novel genes coding for small expressed RNAs

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An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

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An extensive class of small RNAs in Caenorhabditis elegans

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Identification of tissue-specific microRNAs from mouse

31 March 2020

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31 March 2020

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Endogenous and silencing-associated small RNAs in plants

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Prediction of plant microRNA targets

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miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

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The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

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Direct interaction of the spinal muscular atrophy disease protein SMN with the small nucleolar RNA-associated protein fibrillarin

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A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs

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SMN interacts with a novel family of hnRNP and spliceosomal proteins

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The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1

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A functional interaction between the survival motor neuron complex and RNA polymerase II

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A microRNA in a multiple-turnover RNAi enzyme complex

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

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Modulation of HIV-1 replication by RNA interference

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Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase.

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An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus

31 March 2020

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On the role of RNA amplification in dsRNA-triggered gene silencing

31 March 2020

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Analysis of gene function in somatic mammalian cells using small interfering RNAs

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dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference

31 March 2020

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Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

31 March 2020

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

31 March 2020

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siRNA-directed inhibition of HIV-1 infection

31 March 2020

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Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

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Detection of antisense and ribozyme accessible sites on native mRNAs: application to NCOA3 mRNA.

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Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts

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Gene silencing as an adaptive defence against viruses

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Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

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Short interfering RNA confers intracellular antiviral immunity in human cells

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Inhibition of retroviral pathogenesis by RNA interference.

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Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

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RNA interference in adult mice.

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Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

31 March 2020

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Induction and suppression of RNA silencing by an animal virus

31 March 2020

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Regulation of ribonuclease III processing by double-helical sequence antideterminants

31 March 2020

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A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III.

31 March 2020

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Recognition of a conserved class of RNA tetraloops by Saccharomyces cerevisiae RNase III

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Heritable gene silencing in Drosophila using double-stranded RNA.

31 March 2020

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Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes

31 March 2020

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Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana

31 March 2020

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Total silencing by intron-spliced hairpin RNAs

31 March 2020

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Stable suppression of gene expression by RNAi in mammalian cells

31 March 2020

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RNAi in mouse oocytes and preimplantation embryos: effectiveness of hairpin dsRNA.

31 March 2020

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A system for stable expression of short interfering RNAs in mammalian cells

31 March 2020

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Effective expression of small interfering RNA in human cells

31 March 2020

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U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

31 March 2020

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A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

31 March 2020

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Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

31 March 2020

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Gene silencing using micro-RNA designed hairpins

31 March 2020

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Role of PHABULOSA and PHAVOLUTA in determining radial patterning in shoots

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The GRAS gene family in Arabidopsis: sequence characterization and basic expression analysis of the SCARECROW-LIKE genes.

31 March 2020

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Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

31 March 2020

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The rde-1 gene, RNA interference, and transposon silencing in C. elegans

31 March 2020

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Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells

31 March 2020

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Quality control of receptor-kinase signaling complexes

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The exocyst is a Ral effector complex

31 March 2020

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Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

31 March 2020

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Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes

31 March 2020

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Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)

31 March 2020

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Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

31 March 2020

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Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG908

1 reference

PubMed ID

12360232

Dimensions Publication ID

5 August 2017

0 references

1 reference

PubMed ID

12360232