G-protein-coupled receptor oligomerization and its potential for drug discovery (Q34932201)

5 August 2017

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title

G-protein-coupled receptor oligomerization and its potential for drug discovery (English)

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G protein-coupled receptor

5 August 2017

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Susan R George

1

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PubMed ID

12360258

5 August 2017

Brian F O'Dowd

series ordinal

2

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PubMed ID

12360258

5 August 2017

Samuel P Lee

series ordinal

3

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5 August 2017

1 October 2002

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Nature Reviews Drug Discovery

5 August 2017

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5 August 2017

1

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5 August 2017

808-820

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5 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrd913

5 August 2017

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cites work

Orphan G-protein-coupled receptors and natural ligand discovery

1 reference

Defects in G protein-coupled signal transduction in human disease

31 March 2020

1 reference

Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications

31 March 2020

1 reference

Molecular tinkering of G protein-coupled receptors: an evolutionary success

31 March 2020

1 reference

Dimerization of cell surface receptors in signal transduction

31 March 2020

1 reference

Functional significance of oligomerization of G-protein-coupled receptors.

31 March 2020

1 reference

Orphan G protein-coupled receptors in the CNS.

31 March 2020

1 reference

Expression of dopamine D3 receptor dimers and tetramers in brain and in transfected cells

31 March 2020

1 reference

A transmembrane domain-derived peptide inhibits D1 dopamine receptor function without affecting receptor oligomerization

31 March 2020

1 reference

Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell

31 March 2020

1 reference

Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity.

31 March 2020

1 reference

Metabotropic glutamate receptor 5 is a disulfide-linked dimer

31 March 2020

1 reference

Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells.

31 March 2020

1 reference

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

31 March 2020

1 reference

A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.

31 March 2020

1 reference

Dimerization of the delta opioid receptor: implication for a role in receptor internalization

31 March 2020

1 reference

Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity

31 March 2020

1 reference

Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers

31 March 2020

1 reference

G-protein-coupled receptor heterodimerization modulates receptor function

31 March 2020

1 reference

Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties

31 March 2020

1 reference

Structural implication for receptor oligomerization from functional reconstitution studies of mutant V2 vasopressin receptors.

31 March 2020

1 reference

Chemokine receptor homo- or heterodimerization activates distinct signaling pathways

31 March 2020

1 reference

Detergent interaction with band 3, a model polytopic membrane protein

31 March 2020

1 reference

Steroid hormone receptors: evolution, ligands, and molecular basis of biologic function.

31 March 2020

1 reference

The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated

31 March 2020

1 reference

Synaptic membrane G proteins are complexed with tubulin in situ.

31 March 2020

1 reference

β-Adrenergic receptors: Evidence for negative cooperativity

31 March 2020

1 reference

Guanine nucleotide-induced positive cooperativity in muscarinic-cholinergic antagonist binding

31 March 2020

1 reference

Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors

31 March 2020

1 reference

Dopamine D2 receptor dimer formation: evidence from ligand binding

31 March 2020

1 reference

Negative cooperativity in the human bradykinin B2 receptor.

31 March 2020

1 reference

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

31 March 2020

1 reference

Protein oligomerization in the endoplasmic reticulum

31 March 2020

1 reference

Sorting proteins to their target membranes

31 March 2020

1 reference

Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32.

31 March 2020

1 reference

Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function

31 March 2020

1 reference

The splice variant D3nf reduces ligand binding to the D3 dopamine receptor: evidence for heterooligomerization

31 March 2020

1 reference

Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1

31 March 2020

1 reference

Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation

31 March 2020

1 reference

Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor

31 March 2020

1 reference

Role of heteromer formation in GABAB receptor function

31 March 2020

1 reference

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

31 March 2020

1 reference

Heterodimerization is required for the formation of a functional GABA(B) receptor

31 March 2020

1 reference

Intracellular retention of recombinant GABAB receptors

31 March 2020

1 reference

A trafficking checkpoint controls GABA(B) receptor heterodimerization

31 March 2020

1 reference

Oligomerization of opioid receptors: generation of novel signaling units

31 March 2020

1 reference

Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A).

31 March 2020

1 reference

Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness

31 March 2020

1 reference

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer

31 March 2020

1 reference

Crystal structure of rhodopsin: A G protein-coupled receptor

31 March 2020

1 reference

Identification and molecular characterization of m3 muscarinic receptor dimers.

31 March 2020

1 reference

Oligomerization of dopamine and serotonin receptors

31 March 2020

1 reference

Dopamine D2 receptor dimers and receptor-blocking peptides

31 March 2020

1 reference

Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction

31 March 2020

1 reference

Disulfide bonds in the extracellular calcium-polyvalent cation-sensing receptor correlate with dimer formation and its response to divalent cations in vitro.

31 March 2020

1 reference

Involvement of the amino terminus of the B(2) receptor in agonist-induced receptor dimerization.

31 March 2020

1 reference

International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function

31 March 2020

1 reference

C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

31 March 2020

1 reference

31 March 2020

1 reference

Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: interaction in the recognition of endothelin-1 between ETA and ETB receptors.

31 March 2020

1 reference

Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer

31 March 2020

1 reference

Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

31 March 2020

1 reference

Gonadotropin-releasing hormone receptor microaggregation. Rate monitored by fluorescence resonance energy transfer

31 March 2020

1 reference

Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses.

31 March 2020

1 reference

Serotonin Dimers: Application of the Bivalent Ligand Approach to the Design of New Potent and Selective 5-HT1B/1DAgonists

31 March 2020

1 reference

Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist

31 March 2020

1 reference

Simultaneous activation of two different receptor systems by enkephalin/neurotensin conjugates having spacer chains of various lengths

31 March 2020

1 reference

Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists

31 March 2020

1 reference

Gonadotropin releasing hormone activation is mediated by dimerization of occupied receptors.

31 March 2020

1 reference

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

31 March 2020

1 reference

Inhibition of G-protein-coupled receptor function by disruption of transmembrane domain interactions.

31 March 2020

1 reference

Preventing estrogen receptor action with dimer-interface peptides

31 March 2020

1 reference

Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation

31 March 2020

1 reference

Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization

31 March 2020

1 reference

The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2

31 March 2020

1 reference

Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes

31 March 2020

1 reference

A new approach to docking in the beta 2-adrenergic receptor that exploits the domain structure of G-protein-coupled receptors

31 March 2020

1 reference

Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors

31 March 2020

1 reference

Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants.

31 March 2020

1 reference

The probable arrangement of the helices in G protein-coupled receptors.

31 March 2020

1 reference

A peptide agonist acts by occupation of a monomeric G protein-coupled receptor: dual sites of covalent attachment to domains near TM1 and TM7 of the same molecule make biologically significant domain-swapped dimerization unlikely

31 March 2020

1 reference

Immunological identification of A1adenosine receptors in brain cortex

31 March 2020

1 reference

HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization.

31 March 2020

1 reference

Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor

31 March 2020

1 reference

Oligomer formation of histamine H2 receptors expressed in Sf9 and COS7 cells

31 March 2020

1 reference

Discovery of a novel member of the histamine receptor family

31 March 2020

1 reference

Biological actions of monoclonal luteinizing hormone/human chorionic gonadotropin receptor antibodies

31 March 2020

1 reference

Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer

31 March 2020

1 reference

Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition

31 March 2020

1 reference

Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs

31 March 2020

1 reference

Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization.

31 March 2020

1 reference

G-protein-coupled receptors function as oligomers in vivo

31 March 2020

1 reference

Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis

31 March 2020

1 reference

Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed

31 March 2020

1 reference

Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes.

31 March 2020

1 reference

Heteromeric association creates a P2Y-like adenosine receptor

31 March 2020

1 reference

The angiotensin II AT2 receptor is an AT1 receptor antagonist.

31 March 2020

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D2/D3 dopamine receptor heterodimers exhibit unique functional properties

31 March 2020

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GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

31 March 2020

1 reference

An amino-acid taste receptor

31 March 2020

1 reference

Mammalian sweet taste receptors

31 March 2020

1 reference

Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes

31 March 2020

1 reference

A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists

31 March 2020

1 reference

Synthesis and characterization of bivalent peptide ligands targeted to G-protein-coupled receptors

31 March 2020

1 reference

From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes

31 March 2020

1 reference

Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide "address" recognition at kappa opioid receptors

31 March 2020

1 reference

The novel heteromeric bivalent ligand SB9 potently antagonizes P2Y(1) receptor-mediated responses

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD913

1 reference

5 August 2017

1 reference

PubMed ID

12360258