Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1) (Q34933960)

5 August 2017

title

Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1) (English)

1 reference

5 August 2017

1 reference

Daniela Schuster

9

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Gerhard Wolber

object named as

Gerhard Wolber

6

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Judith M Rollinger

object named as

Judith M Rollinger

7

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Birgit Waltenberger

1

object named as

Birgit Waltenberger

1 reference

5 August 2017

8

Oliver Werz

1 reference

5 August 2017

10

Hermann Stuppner

1 reference

5 August 2017

Katja Wiechmann

2

1 reference

5 August 2017

Julia Bauer

3

1 reference

5 August 2017

Patrick Markt

4

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5 August 2017

Stefan M Noha

5

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5 August 2017

language of work or name

English

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publication date

20 April 2011

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5 August 2017

number of pages

12

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Journal of Medicinal Chemistry

inferred from page(s)

published in

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5 August 2017

volume

54

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5 August 2017

issue

9

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5 August 2017

page(s)

3163-3174

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Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol

5 August 2017

cites work

1 reference

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8 July 2018

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8 July 2018

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Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

8 July 2018

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Network pharmacology: the next paradigm in drug discovery

8 July 2018

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Structural basis for induced formation of the inflammatory mediator prostaglandin E2.

8 July 2018

1 reference

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Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target

8 July 2018

1 reference

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Human microsomal prostaglandin E synthase-1 (mPGES-1) binding with inhibitors and the quantitative structure-activity correlation.

8 July 2018

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8 July 2018

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Membrane prostaglandin E synthase-1: a novel therapeutic target

8 July 2018

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Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy

8 July 2018

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Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

8 July 2018

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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

8 July 2018

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Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept.

8 July 2018

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Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

8 July 2018

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Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

8 July 2018

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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

26 October 2018

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3D-QSAR study of microsomal prostaglandin E2 synthase (mPGES-1) inhibitors.

26 October 2018

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Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists

26 October 2018

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Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors

26 October 2018

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Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids

26 October 2018

1 reference

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Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

26 October 2018

1 reference

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26 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21466167

12 December 2020

inferred from PubMed ID database lookup

The scaffold hopping potential of pharmacophores

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21466167

12 December 2020

inferred from PubMed ID database lookup

Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21466167

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/JM101309G

1 reference

5 August 2017

1 reference

5 August 2017

1 reference