Mapping the limits of substrate specificity of the adenylation domain of TycA. (Q34935927)

5 August 2017

Mapping the limits of substrate specificity of the adenylation domain of TycA. (English)

1 reference

5 August 2017

Florian Hollfelder

2

1 reference

5 August 2017

1

1 reference

5 August 2017

1 March 2009

1 reference

5 August 2017

1 reference

5 August 2017

10

1 reference

5 August 2017

671-682

1 reference

5 August 2017

4

1 reference

Bioactive microbial metabolites

5 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

New antibiotics from bacterial natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Substrate recognition by nonribosomal peptide synthetase multi-enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Portability of epimerization domain and role of peptidyl carrier protein on epimerization activity in nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Assembly of aryl-capped siderophores by modular peptide synthetases and polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Combinatorial biosynthesis--potential and problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Enzymes with extra talents: moonlighting functions and catalytic promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Catalytic promiscuity and the evolution of new enzymatic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Enzyme promiscuity: mechanism and applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Enzyme promiscuity: evolutionary and mechanistic aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Enzyme recruitment in evolution of new function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Protein engineers turned evolutionists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Advances in laboratory evolution of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Combinatorial biosynthesis of novel antibiotics related to daptomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Module extension of a non-ribosomal peptide synthetase of the glycopeptide antibiotic balhimycin produced by Amycolatopsis balhimycina

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Accessing natural products by combinatorial biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Polyketide biosynthesis: a millennium review

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Biochemistry. Directing biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Structural aspects of non-ribosomal peptide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Molecular engineering approaches to peptide, polyketide and other antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Crystal structure of the termination module of a nonribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

45 Tyrocidine synthetase system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

The catalytic properties of tyrosyl ribonucleic acid synthetases from Escherichia coli and Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

On the roles of magnesium and spermidine in the isoleucyl-tRNA synthetase reaction. Analysis of the reaction mechanism by total rate equations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Catalytic efficiency and kcat/KM: a useful comparator?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Relationship between activating and editing functions of the adenylation domain of apo-tyrocidin synthetase 1 (apo-TY1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Editing of non-cognate aminoacyl adenylates by peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Computational methods in developing quantitative structure-activity relationships (QSAR): a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Alpha-chymotrypsin: a case study of substituent constants and regression analysis in enzymic structure--activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Direct Brønsted analysis of the restoration of activity to a mutant enzyme by exogenous amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

On the evolution of structure in aminoacyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Evidence for the double-sieve editing mechanism in protein synthesis. Steric exclusion of isoleucine by valyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Enzymatic aminoacylation of tRNA with unnatural amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Utility of epimerization domains for the redesign of nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Natural products--a simple model to explain chemical diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

The evolution of secondary metabolism - a unifying model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Diversifying carotenoid biosynthetic pathways by directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

The genetic theory of adaptation: a brief history

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Natural Selection and the Concept of a Protein Space

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Nonribosomal peptide synthetases-evidence for a second ATP-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Fast kinetic study of yeast phenylalanyl-tRNA synthetase: an efficient discrimination between tyrosine and phenylalanine at the level of the aminoacyladenylate-enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Protein Identification and Analysis Tools on the ExPASy Server

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

An optimized ATP/PP(i)-exchange assay in 96-well format for screening of adenylation domains for applications in combinatorial biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

Characterization of the surfactin synthetase multi-enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200800553

21 January 2018

Identifiers

DOI

10.1002/CBIC.200800553

1 reference

5 August 2017

1 reference

PubMed ID

19189362