Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia (Q34978707)

5 August 2017

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title

Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia (English)

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5 August 2017

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Thomas Sudhop

1

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PubMed ID

12396226

5 August 2017

Klaus von Bergmann

series ordinal

2

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5 August 2017

1 January 2002

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5 August 2017

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5 August 2017

62

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5 August 2017

2333-2347

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5 August 2017

16

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https://scigraph.springernature.com/pub.10.2165/00003495-200262160-00002

5 August 2017

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cites work

Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects

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12 December 2020

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group

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12 December 2020

Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function

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12 December 2020

The combined effect of inhibiting both ACAT and HMG-CoA reductase may directly induce atherosclerotic lesion regression

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12 December 2020

Selective cholesterol absorption inhibition: a novel strategy in lipid-lowering management.

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12 December 2020

Baycol withdrawn from market

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12 December 2020

Cholesterol and mortality. 30 years of follow-up from the Framingham study

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12 December 2020

Rhabdomyolysis with HMG CoA reductase inhibitors: a class effect?

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12 December 2020

Rhabdomyolysis and HMG-CoA reductase inhibitors

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12 December 2020

Garlic preparations for prevention of atherosclerosis

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12 December 2020

In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

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12 December 2020

MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion

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12 December 2020

Reduction of Serum Cholesterol with Sitostanol-Ester Margarine in a Mildly Hypercholesterolemic Population

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12 December 2020

Preclinical safety evaluation of avasimibe in beagle dogs: an ACAT inhibitor with minimal adrenal effects

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12 December 2020

Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study

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12 December 2020

Reduction of blood cholesterol in man.

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12 December 2020

A comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats

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12 December 2020

Comparison of intestinal absorption of cholesterol with different plant sterols in man.

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12 December 2020

The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators

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12 December 2020

New advances in lipid-modifying therapies for reducing cardiovascular risk

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12 December 2020

Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk

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12 December 2020

Statin-fibrate combination therapy

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12 December 2020

Efficacy and short-term safety of a new ACAT inhibitor, avasimibe, on lipids, lipoproteins, and apolipoproteins, in patients with combined hyperlipidemia

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12 December 2020

The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits

1 reference

12 December 2020

Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries; principal results from EUROASPIRE II Euro Heart Survey Programme

1 reference

12 December 2020

The ACAT inhibitor, CI-1011 is effective in the prevention and regression of aortic fatty streak area in hamsters

1 reference

12 December 2020

Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)

1 reference

12 December 2020

Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells.

1 reference

12 December 2020

Sterol content of foods of plant origin

1 reference

12 December 2020

Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans

1 reference

12 December 2020

Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte

1 reference

12 December 2020

Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus

1 reference

12 December 2020

The lipid treatment assessment project (L-TAP): a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals

1 reference

12 December 2020

Assessment of a multiple-dose drug interaction between ezetimibe, a novel selective cholesterol absorption inhibitor and gemfibrozil.

1 reference

12 December 2020

Clinical reality of coronary prevention guidelines: a comparison of EUROASPIRE I and II in nine countries. EUROASPIRE I and II Group. European Action on Secondary Prevention by Intervention to Reduce Events

1 reference

12 December 2020

Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice

1 reference

12 December 2020

An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells

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12 December 2020

Apparent lack of conversion of sitosterol into C24-bile acids in humans

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12 December 2020

State of the art in cholesterol management: targeting multiple pathways

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12 December 2020

Analysis of the degree of undertreatment of hyperlipidemia and congestive heart failure secondary to coronary artery disease

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12 December 2020

Inhibition of intestinal cholesterol absorption by ezetimibe in humans

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12 December 2020

Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption

1 reference

12 December 2020

Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia

1 reference

12 December 2020

Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates

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12 December 2020

Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663

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12 December 2020

Microsomal triglyceride transfer protein is essential for hepatic secretion of apoB-100 and apoB-48 but not triglyceride

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12 December 2020

Determination of cholesterol absorption in man by intestinal perfusion

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12 December 2020

The plasma concentration and LDL-C relationship in patients receiving ezetimibe

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12 December 2020

Effects of sucrose polyester on cholesterol metabolism in man

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12 December 2020

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

1 reference

12 December 2020

The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level.

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12 December 2020

Effects of diets enriched with two different plant stanol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations

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12 December 2020

Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population

1 reference

12 December 2020

ApoB100 secretion from HepG2 cells is decreased by the ACAT inhibitor CI-1011: an effect associated with enhanced intracellular degradation of ApoB

1 reference

12 December 2020

Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels

1 reference

12 December 2020

Ezetimibe, a potent cholesterol absorption inhibitor, normalizes combined dyslipidemia in obese hyperinsulinemic hamsters

1 reference

12 December 2020

Plant sterol and stanol margarines and health

1 reference

12 December 2020

A population pharmacokinetic model that describes multiple peaks due to enterohepatic recirculation of ezetimibe

1 reference

12 December 2020

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets

1 reference

12 December 2020

alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity

1 reference

12 December 2020

Turnover of low density lipoproteins during inhibition of cholesterol absorption by neomycin

1 reference

12 December 2020

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors

1 reference

12 December 2020

Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: clinical and experimental evidence

1 reference

12 December 2020

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

1 reference

12 December 2020

Identification of binding proteins for cholesterol absorption inhibitors as components of the intestinal cholesterol transporter

1 reference

12 December 2020

Treatment of Hypercholesterolemia with Neomycin — A Time for Reappraisal

1 reference

12 December 2020

Randomised controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterol-enriched fat spread

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12 December 2020

Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: pooled analysis of two phase II studies

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12 December 2020

Lack of regression of atherosclerotic lesions in phytosterol-treated apo E-deficient mice

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12 December 2020

Effects of partial replacement of dietary fat by olestra on dietary cholesterol absorption in man

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12 December 2020

Cholesterol absorption inhibition: a strategy for cholesterol-lowering therapy

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12 December 2020

Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice

1 reference

12 December 2020

CI-1011 lowers lipoprotein(a) and plasma cholesterol concentrations in chow-fed cynomolgus monkeys

1 reference

12 December 2020

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits

1 reference

12 December 2020

Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

1 reference

12 December 2020

Effects of the ACAT inhibitor CL 277,082 on cholesterol metabolism in humans

1 reference

12 December 2020

The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.

1 reference

12 December 2020

Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms.

1 reference

12 December 2020

Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia

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12 December 2020

Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters

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12 December 2020

Inhibition of apolipoprotein B and triglyceride secretion in human hepatoma cells (HepG2).

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12 December 2020

Future outlook: changing perspectives on best practice.

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12 December 2020

Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents

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12 December 2020

Novel approaches to lipid lowering: what is on the horizon?

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12 December 2020

Dietary phytosterols: a review of metabolism, benefits and side effects

1 reference

12 December 2020

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

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12 December 2020

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).

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12 December 2020

Effect of plant sterol esters on the absorption of dietary cholesterol

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12 December 2020

Inactivation of microsomal triglyceride transfer protein impairs the normal redistribution but not the turnover of newly synthesized glycerolipid in the cytosol, endoplasmic reticulum and Golgi of primary rat hepatocytes

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12 December 2020

Atorvastatin: an updated review of its pharmacological properties and use in dyslipidaemia

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12 December 2020

Drug interactions of the statins and consequences for drug selection.

1 reference

12 December 2020

Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs

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12 December 2020

Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy

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12 December 2020

Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly

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12 December 2020

Acyl coenzyme A: cholesterol acyltransferase inhibition and hepatic apolipoprotein B secretion

1 reference

12 December 2020

Plasma and biliary cholestanol related to steroid metabolism in familial hypercholesterolemia patients with and without ileal exclusion

1 reference

12 December 2020

Absorption and metabolism of dietary cholesterol

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12 December 2020

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1 reference

12 December 2020

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity

1 reference

12 December 2020

1 reference

12 December 2020

Studies on plasma lipoproteins during absorption of exogenous lecithin in man

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12 December 2020

Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes

1 reference

12 December 2020

Effects of neomycin on absorption, synthesis, and/or flux of cholesterol in man

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12 December 2020

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia

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12 December 2020

Effects of Neomycin Alone and in Combination with Cholestyramine on Serum Cholesterol and Fecal Steroids in Hypercholesterolemic Subjects

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12 December 2020

Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein

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12 December 2020

The Münster Heart Study (PROCAM). Results of follow-up at 8 years.

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12 December 2020

Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects

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12 December 2020

Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT).

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12 December 2020

Lecithin intake and serum cholesterol

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12 December 2020

The molecular basis of abetalipoproteinemia

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12 December 2020

Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol

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12 December 2020

Evaluation of deuterated cholesterol and deuterated sitostanol for measurement of cholesterol absorption in humans

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12 December 2020

Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice: possible mechanisms of action

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12 December 2020

10.2165/00003495-200262160-00002

Identifiers

DOI

1 reference

PubMed ID

12396226

Dimensions Publication ID

5 August 2017

0 references

1 reference

PubMed ID

12396226