Regulation and chance in the ontogeny of B and T cell antigen receptor repertoires (Q34981948)

5 August 2017

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title

Regulation and chance in the ontogeny of B and T cell antigen receptor repertoires (English)

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5 August 2017

Michael Zemlin

1

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author name string

Robert L Schelonka

series ordinal

2

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5 August 2017

Karl Bauer

series ordinal

3

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5 August 2017

Harry W Schroeder

series ordinal

4

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5 August 2017

1 January 2002

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5 August 2017

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5 August 2017

26

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5 August 2017

1-3

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5 August 2017

265-278

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https://scigraph.springernature.com/pub.10.1385/ir:26:1-3:265

5 August 2017

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cites work

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Mechanisms that generate human immunoglobulin diversity operate from the 8th week of gestation in fetal liver

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Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life

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Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire

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Somatic generation of antibody diversity

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IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth.

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Virgin and memory T cells have different requirements for activation via the CD2 molecule.

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Biased utilization of DHQ52 and JH4 gene segments in a human Ig transgenic minilocus is independent of antigenic selection.

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Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

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Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

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Longitudinal survey of lymphocyte subpopulations in the first year of life.

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12 December 2020

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Expression pattern of the most JH-proximal human VH gene segment (VH6) in the B cell and antibody repertoire suggests a role of VH6-encoded IgM antibodies in early ontogeny

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VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

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Terminal deoxynucleotidyl transferase and repertoire development

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Predominant V-region gene configurations in the human antibody response to Haemophilus influenzae capsule polysaccharide

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Efficient immune responses in mice lacking N-region diversity

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Developmental regulation of D beta reading frame and junctional diversity in T cell receptor-beta transcripts from human thymus

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12 December 2020

Identifiers

DOI

10.1385/IR:26:1-3:265

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Dimensions Publication ID

5 August 2017

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