UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients (Q34984788)

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English	UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients	scientific article

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scholarly article

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Europe PubMed Central

5 August 2017

UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients (English)

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Europe PubMed Central

5 August 2017

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D Kuypers

7

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author name string

R H N van Schaik

1

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M van Agteren

2

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J W de Fijter

3

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A Hartmann

4

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5 August 2017

J Schmidt

5

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K Budde

6

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Y Le Meur

8

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M van der Werf

9

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R Mamelok

10

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T van Gelder

11

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publication date

3 June 2009

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Clinical Pharmacology & Therapeutics

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5 August 2017

86

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319-327

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3

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5 August 2017

https://scigraph.springernature.com/pub.10.1038/clpt.2009.83

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Mycophenolate mofetil and its mechanisms of action

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https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

Mycophenolates in transplantation

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https://api.crossref.org/works/10.1038%2FCLPT.2009.83

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The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

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Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

1 reference

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Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats

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https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.

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https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

Identification of glucoside and carboxyl-linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil

1 reference

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21 January 2018

A randomized double-blind, multicenter plasma concentration controlled study of the safety and efficacy of oral mycophenolate mofetil for the prevention of acute rejection after kidney transplantation.

1 reference

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Pharmacokinetic and metabolic investigations of mycophenolic acid in pediatric patients after renal transplantation: implications for therapeutic drug monitoring. German Study Group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant Reci

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https://api.crossref.org/works/10.1038%2FCLPT.2009.83

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Early adequate mycophenolic acid exposure is associated with less rejection in kidney transplantation

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Comparing mycophenolate mofetil regimens for de novo renal transplant recipients: the fixed-dose concentration-controlled trial

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Mycophenolic Acid Pharmacodynamics and Pharmacokinetics Provide a Basis for Rational Monitoring Strategies

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Immunosuppression with mycophenolic acid: one size does not fit all.

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Mycophenolate mofetil: how to further improve using an already successful drug?

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Does the evidence support the use of mycophenolate mofetil therapeutic drug monitoring in clinical practice? A systematic review.

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Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: a population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

Current target ranges of mycophenolic acid exposure and drug-related adverse events: a 5-year, open-label, prospective, clinical follow-up study in renal allograft recipients.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

Population pharmacokinetic modelling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

21 January 2018

CYP3A5 genotype is not associated with a higher risk of acute rejection in tacrolimus-treated renal transplant recipients.

1 reference

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21 January 2018

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs

1 reference

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Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes

1 reference

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Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid

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Pharmacokinetics and protein adduct formation of the pharmacologically active acyl glucuronide metabolite of mycophenolic acid in pediatric renal transplant recipients

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Predicting response to lithium in mood disorders: role of genetic polymorphisms

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A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

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Characterizing the role of enterohepatic recycling in the interactions between mycophenolate mofetil and calcineurin inhibitors in renal transplant patients by pharmacokinetic modelling.

1 reference

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Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein

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Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

1 reference

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Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.83

7 January 2021

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The pharmacokinetic-pharmacodynamic relationship for mycophenolate mofetil in renal transplantation

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Allergic skin and systemic reactions in a patient with pure red cell aplasia and anti-erythropoietin antibodies challenged with different epoetins

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The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers

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Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

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Influence of the UGT2B7 promoter region and exon 2 polymorphisms and comedications on Acyl-MPAG production in vitro and in adult renal transplant patients

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10.1038/CLPT.2009.83

1 reference

Europe PubMed Central

5 August 2017

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1 reference

Europe PubMed Central

5 August 2017

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