The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs (Q34992627)

5 August 2017

The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs (English)

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5 August 2017

endocannabinoid system

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5

Tommaso Cassano

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5 August 2017

Adele Romano

3

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author name string

Silvana Gaetani

1

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5 August 2017

Pasqua Dipasquale

2

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5 August 2017

Laura Righetti

4

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5 August 2017

Daniele Piomelli

6

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5 August 2017

Vincenzo Cuomo

7

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5 August 2017

language of work or name

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1 January 2009

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International Review of Neurobiology

5 August 2017

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5 August 2017

85

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5 August 2017

57-72

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Changes in anxiety feelings following marihuana smoking. The alternation in feelings of anxiety resulting from the smoking of marihuana (Cannabis sativa L.).

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Functional role of high-affinity anandamide transport, as revealed by selective inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

New approaches to antidepressant drug discovery: beyond monoamines

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Anxiolytic-like properties of the anandamide transport inhibitor AM404.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

The time course and significance of cannabis withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Review of the validity and significance of cannabis withdrawal syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Mechanisms of emotional arousal and lasting declarative memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Targeting the endocannabinoid system: to enhance or reduce?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Brain monoglyceride lipase participating in endocannabinoid inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Role of endogenous cannabinoids in synaptic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Anandamide hydrolysis: a new target for anti-anxiety drugs?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Adverse effects of cannabis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

An endocannabinoid mechanism for stress-induced analgesia.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Modulation of anxiety through blockade of anandamide hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Molecular composition of the endocannabinoid system at glutamatergic synapses.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

A biosynthetic pathway for anandamide

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Multiple pathways involved in the biosynthesis of anandamide

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

The endogenous cannabinoid system controls extinction of aversive memories

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Involvement of CB1 cannabinoid receptors in emotional behaviour.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

The neurobiology and control of anxious states

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Interactions of marijuana and induced stress: forearm blood flow, heart rate, and skin conductance

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolysing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Neurobehavioral effects of delta 9-THC and cannabinoid (CB1) receptor gene expression in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

The molecular logic of endocannabinoid signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Structural determinants for recognition and translocation by the anandamide transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

An anorexic lipid mediator regulated by feeding.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

The lipid messenger OEA links dietary fat intake to satiety.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Receptor-dependent formation of endogenous cannabinoids in cortical neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

A second endogenous cannabinoid that modulates long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Cannabis use and anxiety in daily life: a naturalistic investigation in a non-clinical population.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

The N-acylethanolamine-hydrolyzing acid amidase (NAAA).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

A cross-study comparison of cannabis and tobacco withdrawal.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

A within-subject comparison of withdrawal symptoms during abstinence from cannabis, tobacco, and both substances

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Endocannabinoid system and stress and anxiety responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Comparison of the subjective effects of Delta(9)-tetrahydrocannabinol and marijuana in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

A second fatty acid amide hydrolase with variable distribution among placental mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2809%2985005-8

7 January 2021

10.1016/S0074-7742(09)85005-8

Identifiers

DOI

1 reference

5 August 2017

1 reference