Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation (Q34994221)

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English	Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation	scientific article

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22 February 2020

Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation (English)

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22 February 2020

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22 February 2020

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22 February 2020

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Enca Martin-Rendon

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22 February 2020

Derek J Blake

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22 February 2020

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23 August 2013

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22 February 2020

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22 February 2020

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22 February 2020

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22 February 2020

e73169

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22 February 2020

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23 August 2013

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0 references

Associations between TCF4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls

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TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease

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TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders

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The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer

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Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects

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Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis

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8 July 2018

Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.

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8 July 2018

The ins and outs of the epithelial to mesenchymal transition in health and disease

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Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

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Regulation of neural process growth, elaboration and structural plasticity by NF-κB.

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A critical role for IGF-II in memory consolidation and enhancement.

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8 July 2018

TCF4, schizophrenia, and Pitt-Hopkins Syndrome

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8 July 2018

Regulation of plasmacytoid dendritic cell development.

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8 July 2018

MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations

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Common variants conferring risk of schizophrenia

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8 July 2018

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

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TRIM32 is an E3 ubiquitin ligase for dysbindin

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8 July 2018

The class I bHLH factors E2-2A and E2-2B regulate EMT.

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8 July 2018

Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome

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8 July 2018

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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8 July 2018

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Context dependence of proneural bHLH proteins

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Mowat-Wilson syndrome

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The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors

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Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome)

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Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction

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SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA

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The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

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Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4.

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21 January 2018

Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome.

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21 January 2018

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21 January 2018

GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex.

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21 January 2018

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0073169

21 January 2018

A gain-of-glycosylation mutation associated with myoclonus-dystonia syndrome affects trafficking and processing of mouse ε-sarcoglycan in the late secretory pathway.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0073169

21 January 2018

The Schizophrenia Risk Allele C of the TCF4 rs9960767 Polymorphism Disrupts Sensorimotor Gating in Schizophrenia Spectrum and Healthy Volunteers

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0073169

21 January 2018

Transcription factor 4 and myocyte enhancer factor 2C mutations are not common causes of Rett syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/24058414

12 December 2020

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10.1371/JOURNAL.PONE.0073169

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22 February 2020

2013PLoSO...873169F

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22 February 2020

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22 February 2020

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