Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis (Q34997730)

5 August 2017

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis (English)

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5 August 2017

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Frank Echtermeyer

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Jessica Bertrand

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Rita Dreier

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Ingmar Meinecke

4

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Katja Neugebauer

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Martin Fuerst

6

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Yun Jong Lee

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Yeong Wook Song

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Christine Herzog

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Gregor Theilmeier

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Thomas Pap

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language of work or name

English

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publication date

16 August 2009

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1072-1076

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9

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https://scigraph.springernature.com/pub.10.1038/nm.1998

5 August 2017

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cites work

Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers

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12 December 2020

Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4

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12 December 2020

Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression

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12 December 2020

The burden of musculoskeletal disease--a global perspective

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12 December 2020

Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).

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12 December 2020

Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3

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12 December 2020

Syndecan-4 modulates focal adhesion kinase phosphorylation

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12 December 2020

Syndecans: new kids on the signaling block

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12 December 2020

Development of osteoarthritis in the knee joints of Wistar rats after strenuous running exercise in a running wheel by intracranial self-stimulation

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12 December 2020

Validity of histopathological grading of articular cartilage from osteoarthritic knee joints

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12 December 2020

Semiquantitative reverse transcription-polymerase chain reaction analysis of syndecan-1 and -4 messages in cartilage and cultured chondrocytes from osteoarthritic joints

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12 December 2020

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

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12 December 2020

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

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12 December 2020

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network

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12 December 2020

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

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12 December 2020

Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration.

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12 December 2020

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

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12 December 2020

ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate

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12 December 2020

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

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12 December 2020

Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data

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12 December 2020

Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha

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12 December 2020

ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms

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12 December 2020

Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament

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12 December 2020

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

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12 December 2020

Osteoarthritis development in novel experimental mouse models induced by knee joint instability

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12 December 2020

Differential expression of fibroblast growth factor receptor-1, -2, and -3 and syndecan-1, -2, and -4 in neonatal rat mandibular condyle and calvaria during osteogenic differentiation in vitro

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12 December 2020

The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review

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12 December 2020

Proteolysis of the collagen fibril in osteoarthritis

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12 December 2020

Characterization of proADAMTS5 processing by proprotein convertases.

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12 December 2020

Identifiers

DOI

10.1038/NM.1998

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Dimensions Publication ID

5 August 2017

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