Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. (Q34999834)

5 August 2017

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. (English)

1 reference

5 August 2017

11

Tasuku Honjo

1 reference

5 August 2017

Robin Jeannet

1

0 references

Freddy Radtke

object named as

Freddy Radtke

12

0 references

author name string

Jérôme Mastio

2

1 reference

5 August 2017

Alejandra Macias-Garcia

3

1 reference

5 August 2017

Attila Oravecz

4

1 reference

5 August 2017

Todd Ashworth

5

1 reference

5 August 2017

Anne-Solen Geimer Le Lay

6

1 reference

5 August 2017

Bernard Jost

7

1 reference

5 August 2017

Stéphanie Le Gras

8

1 reference

5 August 2017

Jacques Ghysdael

9

1 reference

5 August 2017

Thomas Gridley

10

1 reference

5 August 2017

Jon C Aster

13

1 reference

5 August 2017

Susan Chan

14

1 reference

5 August 2017

Philippe Kastner

15

1 reference

5 August 2017

language of work or name

English

0 references

publication date

9 September 2010

1 reference

5 August 2017

1 reference

5 August 2017

116

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5 August 2017

25

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5 August 2017

5443-5454

1 reference

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Ikaros represses the transcriptional response to Notch signaling in T-cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Molecular pathogenesis of T-cell leukaemia and lymphoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Notch and T cell malignancy.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Transcription elongation factors repress transcription initiation from cryptic sites.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

TEL-JAK2 transgenic mice develop T-cell leukemia.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Signalling downstream of activated mammalian Notch

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100247

Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20829372

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Acute lymphoblastic leukaemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20829372

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genetic inactivation of Ikaros is a rare event in human T-ALL

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20829372

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2010-05-286658

1 reference

5 August 2017

1 reference

5 August 2017

1 reference