Acyl coenzyme A:cholesterol acyltransferase inhibition: potential atherosclerosis therapy or springboard for other discoveries? (Q35000994)

5 August 2017

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title

Acyl coenzyme A:cholesterol acyltransferase inhibition: potential atherosclerosis therapy or springboard for other discoveries? (English)

1 reference

5 August 2017

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Therese M Heinonen

1

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PubMed ID

12437499

5 August 2017

language of work or name

English

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publication date

1 November 2002

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Expert Opinion on Investigational Drugs

5 August 2017

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5 August 2017

11

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5 August 2017

11

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5 August 2017

1519-1527

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Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes

5 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Cholesterol esters regulate apoB48 secretion in CaCo2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Intracellular mechanisms mediating the inhibition of apoB-containing lipoprotein synthesis and secretion in HepG2 cells by avasimibe (CI-1011), a novel acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Direct effect of an acyl-CoA:cholesterol acyltransferase inhibitor, F-1394, on atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Anti-atherosclerotic properties of the acyl-coenzyme A:cholesterol acyltransferase inhibitor F 12511 in casein-fed New Zealand rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

The combined effect of inhibiting both ACAT and HMG-CoA reductase may directly induce atherosclerotic lesion regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Novel effects of the acyl-coenzyme A:Cholesterol acyltransferase inhibitor 58-035 on foam cell development in primary human monocyte-derived macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Preclinical safety evaluation of avasimibe in beagle dogs: an ACAT inhibitor with minimal adrenal effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Efficacy and short-term safety of a new ACAT inhibitor, avasimibe, on lipids, lipoproteins, and apolipoproteins, in patients with combined hyperlipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Preferential pharmacological inhibition of macrophage ACAT increases plaque formation in mouse and rabbit models of atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.11.1519

10.1517/13543784.11.11.1519

21 January 2018

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12437499