Fatty acids induce amylin expression and secretion by pancreatic beta-cells. (Q35008762)

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10 February 2020

title

Fatty acids induce amylin expression and secretion by pancreatic beta-cells (English)

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10 February 2020

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1

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10 February 2020

Yingying Le

8

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10 February 2020

author name string

Kun Cai

2

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10 February 2020

Oumei Wang

3

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10 February 2020

Zongmeng Li

4

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10 February 2020

Juan Chen

5

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10 February 2020

Bo Deng

6

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10 February 2020

Lihua Qian

7

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publication date

20 October 2009

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American Journal of Physiology - Endocrinology and Metabolism

10 February 2020

published in

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10 February 2020

volume

298

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10 February 2020

issue

1

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page(s)

E99-E107

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Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid.

10 February 2020

cites work

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Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells.

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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

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Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function

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High glucose concentration favors the selective secretion of islet amyloid polypeptide through a constitutive secretory pathway in human pancreatic islets.

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Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide

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High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

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Hyperamylinemia, hyperinsulinemia, and insulin resistance in genetically obese LA/N-cp rats

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Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

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Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes

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21 January 2018

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