Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets (Q35009752)

5 August 2017

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title

Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets (English)

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5 August 2017

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Berislav V Zlokovic

1

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PubMed ID

12453672

5 August 2017

language of work or name

English

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publication date

1 December 2002

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Advanced Drug Delivery Reviews

5 August 2017

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5 August 2017

54

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5 August 2017

12

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5 August 2017

1553-1559

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Alzheimer disease as a vascular disorder: nosological evidence

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer's pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Patterns of brain activation in people at risk for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Vascular risk factors for Alzheimer's disease: an epidemiologic perspective.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Severe cardiovascular disease and Alzheimer's disease: senile plaque formation in cortical areas

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Risk factors and genetic background for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

The relationship between senile plaques and cerebral blood vessels in Alzheimer's disease and senile dementia. Morphological mechanism of senile plaque production.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Vascular variant of Alzheimer's disease characterized by severe plaque-like beta protein angiopathy.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Amyloidosis and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Angiogenesis in cancer and other diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Vascular-specific growth factors and blood vessel formation

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Mechanisms of angiogenesis and arteriogenesis

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Clearing the brain's amyloid cobwebs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Clearance of amyloid beta-peptide from brain: transport or metabolism?

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Metabolic regulation of brain Abeta by neprilysin.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Blood-brain barrier transport of circulating Alzheimer's amyloid beta

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Targeting alzheimer amyloid plaques in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Amyloid beta peptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

Protein S confers neuronal protection during ischemic/hypoxic injury in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900150-3

7 January 2021

10.1016/S0169-409X(02)00150-3

Identifiers

DOI

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5 August 2017

1 reference

PubMed ID

12453672