Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. (Q35010483)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9990087%20AND%20SRC:MED&resulttype=core&format=json

12 December 2019

title

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase (English)

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12 December 2019

3

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12 December 2019

Steinunn Baekkeskov

series ordinal

4

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12 December 2019

author name string

S F Kash

series ordinal

1

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12 December 2019

L H Tecott

series ordinal

2

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12 December 2019

language of work or name

English

0 references

publication date

1 February 1999

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Proceedings of the National Academy of Sciences of the United States of America

12 December 2019

published in

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12 December 2019

volume

96

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12 December 2019

issue

4

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12 December 2019

page(s)

1698-1703

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Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

12 December 2019

cites work

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Region-specific regulation of glutamic acid decarboxylase (GAD) mRNA expression in central stress circuits.

8 July 2018

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Anxiety, defence and the elevated plus-maze

8 July 2018

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Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

8 July 2018

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Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67

8 July 2018

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Hippocampal GABA(A) channel conductance increased by diazepam

8 July 2018

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Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

8 July 2018

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Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures

8 July 2018

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Anxiolytics by ethanol, diazepam and buspirone in a novel murine behavioral assay.

8 July 2018

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Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety.

8 July 2018

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Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.

8 July 2018

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GABAergic synapses. Supramolecular organization and biochemical regulation

8 July 2018

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Drug interactions at the GABA receptor-ionophore complex

8 July 2018

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Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons

8 July 2018

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The use of a plus-maze to measure anxiety in the mouse

8 July 2018

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Proconflict and electrocorticographic effects of drugs modulating GABAergic neurotransmission.

8 July 2018

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Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.

8 July 2018

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Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat.

8 July 2018

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The effects of compounds related to gamma-aminobutyrate and benzodiazepine receptors on behavioural responses to anxiogenic stimuli in the rat: punished barpressing

8 July 2018

1 reference

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GABA and the behavioral effects of anxiolytic drugs

8 July 2018

1 reference

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Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids

8 July 2018

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Electrophysiology of GABAA and GABAB receptor subtypes

8 July 2018

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Two genes encode distinct glutamate decarboxylases

8 July 2018

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GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.

8 July 2018

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Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.

8 July 2018

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Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain

8 July 2018

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Cofactor interactions and the regulation of glutamate decarboxylase activity.

8 July 2018

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GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures

8 July 2018

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GABAergic drugs and conflict behavior in the rat: Lack of similarities with the actions of benzodiazepines

8 July 2018

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8 July 2018

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Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain

8 July 2018

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Enhanced suppressive effects of aversive events induced in rats by picrotoxin: Possibility of a GABA control on behavioral inhibition

8 July 2018

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Different distributions of GAD65 and GAD67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles.

8 July 2018

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Regional differences in cofactor saturation of glutamate decarboxylase (GAD) in discrete brain nuclei of the rat. Effect of repeated administration of haloperidol on GAD activity in the substantia nigra.

21 January 2018

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Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture.

21 January 2018

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The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines.

21 January 2018

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GABAergic influences on plus-maze behaviour in mice.

21 January 2018

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The modified light/dark transition test in mice: evaluation of classic and putative anxiolytic and anxiogenic drugs.

21 January 2018

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The use of the rat elevated plus-maze to discriminate between non-selective and BZ-1 (omega 1) selective, benzodiazepine receptor ligands.

21 January 2018

1 reference

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Changes in tonic immobility and the GABA-benzodiazepine system in response to handling in the chick.

21 January 2018

1 reference

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Sex differences in GABA/benzodiazepine receptor changes and corticosterone release after acute stress in rats.

21 January 2018

1 reference

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Do the reductions in social interaction produced by picrotoxin and pentylenetetrazole indicate anxiogenic actions?

21 January 2018

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The effects of compounds acting at the benzodiazepine receptor complex on the ultrasonic calling of mouse pups.

21 January 2018

1 reference

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Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble

26 October 2018

1 reference

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The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists

26 October 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.96.4.1698

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9990087%20AND%20SRC:MED&resulttype=core&format=json

12 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9990087%20AND%20SRC:MED&resulttype=core&format=json

12 December 2019

1 reference