Altering airway surface liquid volume: inhalation therapy with amiloride and hyperosmotic agents (Q35012425)

5 August 2017

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title

Altering airway surface liquid volume: inhalation therapy with amiloride and hyperosmotic agents (English)

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5 August 2017

1 reference

Andrew J Hirsh

1

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PubMed ID

12458154

5 August 2017

language of work or name

English

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publication date

1 December 2002

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Advanced Drug Delivery Reviews

5 August 2017

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5 August 2017

54

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5 August 2017

1445-1462

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5 August 2017

11

1 reference

Long-term benefits of inhaled tobramycin in adolescent patients with cystic fibrosis

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Nebulized antibiotics in cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Human airway ion transport. Part two.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Human airway ion transport. Part one.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Osmotic water permeabilities of cultured, well-differentiated normal and cystic fibrosis airway epithelia

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Lung disease in cystic fibrosis: is airway surface liquid composition abnormal?

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Evidence for reduced Cl- and increased Na+ permeability in cystic fibrosis human primary cell cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Relative ion permeability of normal and cystic fibrosis nasal epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Bioelectric properties and ion flow across excised human bronchi

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Mucociliary clearance in the airways

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Coordinated clearance of periciliary liquid and mucus from airway surfaces.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Production of beta-defensins by human airway epithelia

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Preservation of Tracheal Mucus by Nonaqueous Fixative

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Volume of airway surface liquid in health and disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

1 reference

7 January 2021

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

1 reference

7 January 2021

Control of mucus hydration as a Donnan equilibrium process

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Mammalian Respiratory Mucociliary Clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

A Method for Standardized Studies of Mucociliary Activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Regulation of mucociliary clearance in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Mucin in disease. Modification of mucin gene expression in airway disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Viscosity versus composition in airway pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Molecular insights into the physiology of the 'thin film' of airway surface liquid

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The CF salt controversy: in vivo observations and therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

In vivo airway surface liquid Cl- analysis with solid-state electrodes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Airway surface liquid osmolality measured using fluorophore-encapsulated liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Elemental content of airway surface liquid from infants with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Structure and function of the CFTR chloride channel

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Increased nasal potential difference and amiloride sensitivity in neonates with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Correlation between nasal potential difference measurements, genotype and clinical condition in patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Effects of topically delivered benzamil and amiloride on nasal potential difference in cystic fibrosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The effect of topical benzamil and amiloride on nasal potential difference in cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Surprises from the airway epithelium.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Aquaporin water channels and lung physiology

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Sodium transport and intracellular sodium activity in cultured human nasal epithelium.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Evaluating routine diuretics after coronary surgery: a prospective randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Potassium-sparing effect of amiloride in a diuretic factorial study in man

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Control of epithelial Na+ conductance by the cystic fibrosis transmembrane conductance regulator

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

CFTR as a cAMP-dependent regulator of sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Amiloride and its analogs as tools in the study of ion transport

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Subunit composition determines the single channel kinetics of the epithelial sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The heterotetrameric architecture of the epithelial sodium channel (ENaC).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Number of subunits comprising the epithelial sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Identification of amino acid residues in the alpha, beta, and gamma subunits of the epithelial sodium channel (ENaC) involved in amiloride block and ion permeation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Structure-activity relationship of amiloride analogs as blockers of epithelial Na channels: I. Pyrazine-ring modifications

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Structure-activity relationship of amiloride analogs as blockers of epithelial Na channels: II. Side-chain modifications

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Molecular recognition of amiloride analogs: a molecular electrostatic potential analysis. 1. Pyrazine ring modifications

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Amiloride-sensitive Na channels

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Amiloride: a molecular probe of sodium transport in tissues and cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Interactions of amiloride and other blocking cations with the apical Na channel in the toad urinary bladder.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The intracellular localization of amiloride in frog skin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Airway deposition and clearance and systemic pharmacokinetics of amiloride following aerosolization with an ultrasonic nebulizer to normal airways

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Deposition, clearance, and effects of aerosolized amiloride in sheep airways

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Regional differences in airway surface liquid composition

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Effects of temperature, relative humidity, and mode of breathing on canine airway secretions

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The effect of pH of douching solutions on mucociliary clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The effect of hypertonicity on nasal mucociliary clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Mucociliary clearance and buffered hypertonic saline solution

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Physiologic and hypertonic saline solutions impair ciliary activity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Hypertonic saline decreases ciliary movement in human nasal epithelium in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Inhalation of dry-powder mannitol increases mucociliary clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Inhalation of dry powder mannitol improves clearance of mucus in patients with bronchiectasis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Nasal hyperosmolar challenge with a dry powder of mannitol in patients with allergic rhinitis. Evidence for epithelial cell involvement

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Inhaled mannitol identifies methacholine-responsive children with active asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Kinetics of Transport of Glucose, Fructose, and Mannitol by Pseudomonas aeruginosa

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Transport and phosphorylation of glucose, fructose, and mannitol by Pseudomonas aeruginosa

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Amiloride. A potassium-sparing natriuretic agent

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Acute and long-term amiloride inhalation in cystic fibrosis lung disease. A rational approach to cystic fibrosis therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Effect of amiloride on human bronchial ciliary activity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Regulation of mucociliary transport. Response of mucous cells to stimulation by amiloride applied to the frog palate in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Nebulised amiloride in respiratory exacerbations of cystic fibrosis: a randomised controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Aerosolized amiloride: dose effect on nasal bioelectric properties, pharmacokinetics, and effect on sputum expectoration in patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900161-8

7 January 2021

10.1016/S0169-409X(02)00161-8

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12458154