Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth (Q35014260)

5 August 2017

Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth (English)

1 reference

5 August 2017

0 references

Benoit Vanhollebeke

10

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author name string

Brad A Haubrich

1

1 reference

5 August 2017

Ujjal K Singha

2

1 reference

5 August 2017

Matthew B Miller

3

1 reference

5 August 2017

Craigen R Nes

4

1 reference

5 August 2017

Hosanna Anyatonwu

5

1 reference

5 August 2017

Laurence Lecordier

6

1 reference

5 August 2017

Presheet Patkar

7

1 reference

5 August 2017

David J Leaver

8

1 reference

5 August 2017

Fernando Villalta

9

1 reference

5 August 2017

Minu Chaudhuri

11

1 reference

5 August 2017

W David Nes

12

1 reference

5 August 2017

25 November 2014

1 reference

Journal of Lipid Research

5 August 2017

1 reference

5 August 2017

56

1 reference

5 August 2017

331-341

1 reference

5 August 2017

2

1 reference

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Drug discovery and human African trypanosomiasis: a disease less neglected?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Drug discovery for neglected diseases: molecular target-based and phenotypic approaches

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

VNI cures acute and chronic experimental Chagas disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Protein translocase of mitochondrial inner membrane in Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Human African trypanosomiasis in non-endemic countries (2000-2010)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Structural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Biosynthesis of cholesterol and other sterols

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

A molecular mechanism for eflornithine resistance in African trypanosomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Functional characterization of human oncoprotein gankyrin in Zebrafish

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Eliminating human African trypanosomiasis: where do we stand and what comes next?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Dual roles for cholesterol in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Cytoprotection by glycine against ATP-depletion-induced injury is mediated by glycine receptor in renal cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Differences in the modulation of collective membrane motions by ergosterol, lanosterol, and cholesterol: a dynamic light scattering study

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Natural products active against African trypanosomes: a step towards new drugs.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Evidence for a Trypanosoma brucei lipoprotein scavenger receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Has nature designed the cholesterol side chain for optimal interaction with phospholipids?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Host plasma low density lipoprotein particles as an essential source of lipids for the bloodstream forms of Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Azasterol inhibition of delta 24-sterol methyltransferase in Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Sterol synergism in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Multiple functions for sterols in Saccharomyces cerevisiae.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei.

8 July 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Direct interaction between amphotericin B and ergosterol in lipid bilayers as revealed by 2H NMR spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Evaluation of azasterols as anti-parasitics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Yeast sterol C24-methyltransferase: role of highly conserved tyrosine-81 in catalytic competence studied by site-directed mutagenesis and thermodynamic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Biosynthesis of phytosterols. Kinetic mechanism for the enzymatic C-methylation of sterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

CYP51 from Trypanosoma brucei is obtusifoliol-specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306687

Plant sterols and the membrane environment

25 October 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M054643

Exogenous and endogenous sources of sterols in the culture-adapted procyclic trypomastigotes of Trypanosoma brucei

21 January 2018

1 reference

12 December 2020

Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei

1 reference

12 December 2020

Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae

1 reference

12 December 2020

Trypanosome sterols and their metabolic origins

1 reference

12 December 2020

Stereochemical specificity for sterols in Saccharomyces cerevisiae

1 reference

12 December 2020

Structural and physiological features of sterols necessary to satisfy bulk membrane and sparking requirements in yeast sterol auxotrophs

1 reference

12 December 2020

The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues

1 reference

12 December 2020

Identifiers

DOI

10.1194/JLR.M054643

1 reference

5 August 2017

1 reference

5 August 2017

1 reference